Knockdown of PTEN Disrupts PINK1/Parkin-mediated Mitophagy and Promotes Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus
Li-Han Lin,
Chung-Yao Hsu,
Chin-Wei Huang
et al.
Abstract:Aberrant mitophagy due to mitochondrial defects via oxidative stress has a strong potential to cause epilepsy. However, PINK1 signaling regarding damaged mitochondria- and oxidative stress-mediated mitophagy during status epilepticus (SE) remains to be fully elucidated. Therefore, the present study aimed to clarify this molecular mechanism in SE animal model. We used pilocarpine-induced SE animal model to investigate the molecular mechanism of SE. Our data exhibited that the hippocampal tissue of rats during S… Show more
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