“…By combining the MO knockdown technique with the fast-developing zebrafish, researchers have identified a dozen genes associated with JBTS. JBTS-causing genes, including AHI (Elsayed et al, 2015 ), CC2D2A (Bachmann-Gagescu et al, 2011 , 2015 ), CEP290 (Baye et al, 2011 ), CSPP1 (Tuz et al, 2014 ), INPP5E (Luo et al, 2012 ; Xu et al, 2017 ), PDE6D (Thomas S. et al, 2014 ), and POC1B (Roosing et al, 2014 ; Zhang et al, 2015 ), have been verified in zebrafish models. Specifically, knocking down inpp5e by MOs lead to microphthalmia, pronephros cysts and pericardial effusion in zebrafish.…”