Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma

Ren, Zhaozhou; Ni, Feifei; Zhang, Tao; Yuan, Xiangnan; Li, Jianjun; Xiao, Wan'an

doi:10.1016/j.yexcr.2021.112636

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Monoclonal antibodies (mAb) are the most recommended targeting agents for cancer cell antigens in order to improve the specific and active targeted PS nanocarrier systems and so enhance the overall efficacy of PDT [68]. Research has highlighted that MM tumor cells typically overexpress surface proteins, such as melanoma inhibitory activity (MIA), TRAIL-receptor, B cell lymphoma 2, integrin α and β proteins, mitochondrial p32 protein, extracellular matrix 1, and a fusion of Drosophilia protein, Caenorhabditis elegans protein, and ephrin type-A receptor 2 (Figure 4) [4,[86][87][88][89]. Currently, trastuzumab, rituximab, and bevacizumab are FDA-approved mAbs that can be utilized for targeting MM cells [86].…”

Section: Active Pdt Nanoparticle-mediated Ps Delivery Platforms For M...mentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nkune

Abrahamse

2021

IJMS

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Metastatic melanoma (MM) is a skin malignancy arising from melanocytes, the incidence of which has been rising in recent years. It poses therapeutic challenges due to its resistance to chemotherapeutic drugs and radiation therapy. Photodynamic therapy (PDT) is an alternative non-invasive modality that requires a photosensitizer (PS), specific wavelength of light, and molecular oxygen. Several studies using conventional PSs have highlighted the need for improved PSs for PDT applications to achieve desired therapeutic outcomes. The incorporation of nanoparticles (NPs) and targeting moieties in PDT have appeared as a promising strategy to circumvent various drawbacks associated with non-specific toxicity, poor water solubility, and low bioavailability of the PSs at targeted tissues. Currently, most studies investigating new developments rely on two-dimensional (2-D) monocultures, which fail to accurately mimic tissue complexity. Therefore, three-dimensional (3-D) cell cultures are ideal models to resemble tumor tissue in terms of architectural and functional properties. This review examines various PS drugs, as well as passive and active targeted PS nanoparticle-mediated platforms for PDT treatment of MM on 2-D and 3-D models. The overall findings of this review concluded that very few PDT studies have been conducted within 3-D models using active PS nanoparticle-mediated platforms, and so require further investigation.

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Section: Active Pdt Nanoparticle-mediated Ps Delivery Platforms For M...mentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nkune

Abrahamse

2021

IJMS

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“…However, although the role of Notch signaling pathway in cancer has been comprehensively investigated, the relationship between human cancer and NLE1 was rarely reported and mains largely unknown. Only few studies concerning malignant melanoma and colon adenocarcinoma indicated that NLE1 may have certain potential in the regulation of tumor growth and prediction of patients’ prognosis ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer

Wang

et al. 2023

Front. Oncol.

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Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer, which is a severer threaten to human health because of its extremely high morbidity and mortality. In this study, the role of Notchless homolog 1 (NLE1) in the development of NSCLC was investigated and the underlying mechanism was explored. The outcomes showed that NLE1 expression is significantly higher in tumor tissues than normal tissues, and is correlated with the pathological stage. The regulation of NSCLC development by NLE1 was also visualized by the in vitro and in vivo loss-of-function studies, which indicated the inhibition of cell growth and migration, as well as enhancement of cell apoptosis on condition of NLE1 knockdown. As for the mechanism, it was demonstrated that NLE1 may execute its tumor-regulating function through activating E2F1-mediated transcription of CDK1, and PI3K/Akt signaling pathway was also supposed as a downstream of NLE1 in the regulation of NSCLC. Both CDK1 overexpression and treatment of Akt pathway activator could reverse the NLE1 knockdown induced NSCLC inhibition to some extent. In conclusion, this study identified NLE1 as a novel tumor promotor in the development and progression of NSCLC, which may be a potential therapeutic target in the treatment of NSCLC.

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The effect of up-regulation of NLE1 gene expression on the invasion and migration of colon cancer cells and its mechanism

Wang

Zhao

2023

Journal of King Saud University - Science

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Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma

Cited by 3 publications

References 21 publications

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer

The effect of up-regulation of NLE1 gene expression on the invasion and migration of colon cancer cells and its mechanism

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