Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells

Xu, Wei; Liu, Shuyi; Zhang, Genshan; Liu, Jin; Cao, Gang

doi:10.1080/1120009x.2022.2143614

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…zebrafish; Richard et al, 2019). It has also been noted that METTL5 expression decreases in aged human tissues (Rong et al, 2020) and gastric cancer (X. K. Wang, Zhang, et al, 2021) but increases in various tumor types (TCGA Research Network), including breast cancer tissue and cell lines (Rong et al, 2020), liver (Peng et al, 2022; W. Xu, Liu, et al, 2022), lung, and pancreatic cancer (H. Huang et al, 2022; S. Sun et al, 2021; Yan et al, 2021; Z. Zhang, Zhang, Luo, et al, 2021). Because the proliferation of breast and liver cancer cell lines decreased upon short interfering RNA knockdown of METTL5 (Peng et al, 2022; Rong et al, 2020; W. Xu, Liu, et al, 2022), METTL5 is a potential target for anti‐cancer therapy.…”

Section: Biological Functions Of Human M6a Rna Mtasesmentioning

confidence: 99%

“…zebrafish;Richard et al, 2019). It has also been noted that METTL5 expression decreases in aged human tissues (Rong et al, 2020) and gastric cancer (X. K. but increases in various tumor types (TCGA Research Network), including breast cancer tissue and cell lines (Rong et al, 2020), liver (Peng et al, 2022;W. Xu, Liu, et al, 2022), lung, and pancreatic cancer (H. Huang et al, 2022;Yan et al, 2021;.…”

Section: A Pair Of Mmentioning

confidence: 99%

“…Xu, Liu, et al, 2022), lung, and pancreatic cancer (H. Huang et al, 2022;Yan et al, 2021;. Because the proliferation of breast and liver cancer cell lines decreased upon short interfering RNA knockdown of METTL5 (Peng et al, 2022;Rong et al, 2020;W. Xu, Liu, et al, 2022), METTL5 is a potential target for anti-cancer therapy.…”

Section: A Pair Of Mmentioning

confidence: 99%

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Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases

Breger,

Kunkler,

O'Leary

et al. 2023

WIREs RNA

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Despite the discovery of modified nucleic acids nearly 75 years ago, their biological functions are still being elucidated. N6‐methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNA (mRNA) and has also been detected in non‐coding RNAs, including long non‐coding RNA, ribosomal RNA, and small nuclear RNA. In general, m6A marks can alter RNA secondary structure and initiate unique RNA–protein interactions that can alter splicing, mRNA turnover, and translation, just to name a few. Although m6A marks in human RNAs have been known to exist since 1974, the structures and functions of methyltransferases responsible for writing m6A marks have been established only recently. Thus far, there are four confirmed human methyltransferases that catalyze the transfer of a methyl group from S‐adenosylmethionine (SAM) to the N6 position of adenosine, producing m6A: methyltransferase‐like protein (METTL) 3/METTL14 complex, METTL16, METTL5, and zinc‐finger CCHC‐domain‐containing protein 4. Though the methyltransferases have unique RNA targets, all human m6A RNA methyltransferases contain a Rossmann fold with a conserved SAM‐binding pocket, suggesting that they utilize a similar catalytic mechanism for methyl transfer. For each of the human m6A RNA methyltransferases, we present the biological functions and links to human disease, RNA targets, catalytic and kinetic mechanisms, and macromolecular structures. We also discuss m6A marks in human viruses and parasites, assigning m6A marks in the transcriptome to specific methyltransferases, small molecules targeting m6A methyltransferases, and the enzymes responsible for hypermodified m6A marks and their biological functions in humans. Understanding m6A methyltransferases is a critical steppingstone toward establishing the m6A epitranscriptome and more broadly the RNome.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein‐RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA‐Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications

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Section: Biological Functions Of Human M6a Rna Mtasesmentioning

confidence: 99%

Section: A Pair Of Mmentioning

confidence: 99%

See 1 more Smart Citation

Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases

Breger,

Kunkler,

O'Leary

et al. 2023

WIREs RNA

View full text Add to dashboard Cite

show abstract

“…METTL5 expression was upregulated in breast cancer tissues and was necessary for the growth of breast cancer cell lines [ 107 ]. High METTL5 expression was associated with the poor prognosis of HCC patients [ 96 ]. The downregulation of METTL5 inhibited HCC cell proliferation, induced cell apoptosis, and decreased the expression of PD-L1, c-Myc, chaperonin-containing TCP1 subunit 2 (CCT2) and Chromobox 3 (CBX3) [ 96 ].…”

Section: Role Of Mettl5 In Cancermentioning

confidence: 99%

“…High METTL5 expression was associated with the poor prognosis of HCC patients [ 96 ]. The downregulation of METTL5 inhibited HCC cell proliferation, induced cell apoptosis, and decreased the expression of PD-L1, c-Myc, chaperonin-containing TCP1 subunit 2 (CCT2) and Chromobox 3 (CBX3) [ 96 ]. Table 1 shows the roles and targets of METTL5 in cancer.…”

Section: Role Of Mettl5 In Cancermentioning

confidence: 99%

Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance

Shim

Jeoung

2023

IJMS

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RNA methylations play critical roles in RNA processes, including RNA splicing, nuclear export, nonsense-mediated RNA decay, and translation. Regulators of RNA methylations have been shown to be differentially expressed between tumor tissues/cancer cells and adjacent tissues/normal cells. N6-methyladenosine (m6A) is the most prevalent internal modification of RNAs in eukaryotes. m6A regulators include m6A writers, m6A demethylases, and m6A binding proteins. Since m6A regulators play important roles in regulating the expression of oncogenes and tumor suppressor genes, targeting m6A regulators can be a strategy for developing anticancer drugs. Anticancer drugs targeting m6A regulators are in clinical trials. m6A regulator-targeting drugs could enhance the anticancer effects of current chemotherapy drugs. This review summarizes the roles of m6A regulators in cancer initiation and progression, autophagy, and anticancer drug resistance. The review also discusses the relationship between autophagy and anticancer drug resistance, the effect of high levels of m6A on autophagy and the potential values of m6A regulators as diagnostic markers and anticancer therapeutic targets.

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METTL5 enhances the mRNA stability of TPRKB through m6A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell

Luo,

Jichun

et al. 2024

Experimental Cell Research

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Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells

Cited by 9 publications

References 28 publications

Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases

Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases

Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance

METTL5 enhances the mRNA stability of TPRKB through m6A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell

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Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells

Cited by 9 publications

References 28 publications

Ghost authors revealed: The structure and function of human N6‐methyladenosine RNA methyltransferases

Ghost authors revealed: The structure and function of human N6‐methyladenosine RNA methyltransferases

Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance

METTL5 enhances the mRNA stability of TPRKB through m6A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell

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Product

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Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases

Ghost authors revealed: The structure and function of human N⁶‐methyladenosine RNA methyltransferases