Knockdown of long non‑coding RNA prostate cancer‑associated transcript 1 inhibits the proliferation and metastasis of tongue squamous cell carcinoma cells by upregulating p21

Yan, Ming; Zhao, Tianjiang; Fu, Lingling; Tian, Rongxiang; Li, Dongzhen; Da, Yunmeng

doi:10.3892/ol.2020.11373

Cited by 3 publications

(4 citation statements)

References 27 publications

(34 reference statements)

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“…The same as BANCR, Yang et al reported that the average OS of OSCC patients with low CASC9 expression was longer than those with high CASC9 expression by Kaplan-analysis, and COX regression analysis also revealed that the CASC9 expression level was an independent predictor of the OSCC prognosis [ 29 ]. In addition, similar reports of other lncRNAs such as LINC01234 [ 73 , 74 ], colon cancer–associated transcript 2 (CCAT2) [ 87 ], FOXD2-AS1 [ 44 ] and FTH1P3 [ 45 ] were also confirmed to be unregulated in OSCC tissues and associated with low OS, which indicated the poor prognostic capability.…”

Section: Translational Potential Of Lncrnas In Osccmentioning

confidence: 60%

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Tang

Fang

Chen

et al. 2021

Cancers

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Oral squamous cell carcinoma (OSCC) is a type of malignancy with high mortality, leading to poor prognosis worldwide. However, the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Recently, the discovery and characterization of long non-coding RNAs (lncRNAs) have revealed their regulatory importance in OSCC. Abnormal expression of lncRNAs has been broadly implicated in the initiation and progress of tumors. In this review, we summarize the functions and molecular mechanisms regarding these lncRNAs in OSCC. In addition, we highlight the crosstalk between lncRNA and tumor microenvironment (TME), and discuss the potential applications of lncRNAs as diagnostic and prognostic tools and therapeutic targets in OSCC. Notably, we also discuss lncRNA-targeted therapeutic techniques including CRISPR-Cas9 as well as immune checkpoint therapies to target lncRNA and the PD-1/PD-L1 axis. Therefore, this review presents the future perspectives of lncRNAs in OSCC therapy, but more research is needed to allow the applications of these findings to the clinic.

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Section: Translational Potential Of Lncrnas In Osccmentioning

confidence: 60%

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Tang

Fang

Chen

et al. 2021

Cancers

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“…The second most significant hit was ‘mTOR signaling pathway’, with an adjusted P -value of 1.04 × 10 − 8 , followed by ‘Adherens junction’, and ‘Cellular senenscence’. Importantly, numerous experiments demonstrated these pathways affect the occurrence and development of tongue squamous cell carcinoma ( Coccè et al , 2017 ; Li et al , 2018 , 2019 ; Lorch et al , 2007 ; Lu et al , 2021 ; Yan et al , 2020 ; Yang et al , 2019 ). It is worth mentioning that the addition of differential ncRNAs information can be significantly enriched to more pathways than the results of mRNA list enrichment analysis alone (see Supplementary Tables S2–S4 for details).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, in the joint list enrichment results, these top-ranked additional enriched pathways have been reported to be definitively associated with tongue squamous cell carcinoma compared to mRNA list analysis alone. ( Coccè et al , 2017 ; Li et al , 2018 , 2019 ; Liao et al , 2021 ; Lorch et al , 2007 ; Lu et al , 2021 ; Yan et al , 2020 ; Yang et al , 2019 ). This use case again demonstrates the practical application of NcPath, which allows for comprehensive analysis using pairings of three RNA classes, and helps researchers focusing on potentially more relevant biological findings.…”

Section: Resultsmentioning

confidence: 99%

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Zhang

Fang

et al. 2022

Bioinformatics

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Summary Noncoding RNAs play important roles in transcriptional processes and participate in the regulation of various biological functions, in particular miRNAs and lncRNAs. Despite their importance for several biological functions, the existing signaling pathway databases do not include information on miRNA and lncRNA. Here, we redesigned a novel pathway database named NcPath by integrating and visualizing a total of 178,308 human experimentally-validated miRNA-target interactions (MTIs), 32,282 experimentally-verified lncRNA target interactions (LTIs), and 4,837 experimentally-validated human ceRNA networks across 222 KEGG pathways (including 27 sub-categories). To expand the application potential of the redesigned NcPath database, we identified 556,798 reliable lncRNA-PCG (protein-coding genes) interaction pairs by integrating co-expression relations, ceRNA relations, co-TF-binding interactions, co-Histone-modification interactions, cis-regulation relations and lncPro Tool predictions between lncRNAs and protein-coding genes. In addition, to determine the pathways in which miRNA/lncRNA targets are involved, we performed a KEGG enrichment analysis using an hypergeometric test. The NcPath database also provides information on MTIs/LTIs/ceRNA networks, PubMed IDs, gene annotations and the experimental verification method used. In summary, the NcPath database will serve as an important and continually updated platform that provides annotation and visualization of the pathways on which noncoding RNAs (miRNA and lncRNA) are involved, and provide support to multimodal noncoding RNAs enrichment analysis. The NcPath database is freely accessible at http://ncpath.pianlab.cn/. Availability and implementation NcPath database is freely available at http://ncpath.pianlab.cn/. The code and manual to use NcPath can be found at https://github.com/Marscolono/NcPath/. Supplementary information Supplementary data are available at Bioinformatics online.

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“…Lin et al 36 noted that PRNCR1 played as one oncogenic lncRNA gene in the development of TSCC via regulating HOXB5/ miR‑944. Yan et al 37 suggested that knockdown of PCAT‐1 suppressed metastasis of proliferation of TSCC cell through up‐regulating P21. Liu and workmates found that knockdown of SNHG17 suppressed TSCC cell migration, invasion and proliferation through regulating miR‐876/SP1 38 .…”

Section: Discussionmentioning

confidence: 99%

lncRNA RPSAP52 induced the development of tongue squamous cell carcinomas via miR‐423‐5p/MYBL2

Gong

et al. 2021

J Cellular Molecular Medi

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Growing lncRNAs have been noted to involve in the initiation and development of several tumours including tongue squamous cell carcinomas (TSCCs). However, the biological role and mechanism of lncRNA RPSAP52 were not well‐explained. We indicated that RPSAP52 was higher in TSCC samples compared with that in control samples. The higher expression of RPSAP52 was positively correlated with higher T stage and TNM stage. Ectopic expression of RPSAP52 induced TSCC cell growth and cycle and induced cytokine secretion including IFN‐γ, IL‐1β and IL‐6, IL‐8, IL‐10 and TGF‐β. We found that the overexpression of RPSAP52 suppressed miR‐423‐5p expression in SCC‐4 cell. miR‐423‐5p was lower in TSCC samples compared with that in control samples, and miR‐423‐5p level was negatively correlated with higher T stage and TNM stage. Pearson's correlation indicated that miR‐423‐5p was negatively associated with that of RPSAP52 in TSCC tissues. Furthermore, MYBL2 was one direct gene of miR‐423‐5p and elevated expression of miR‐423‐5p suppressed MYBL2 expression and ectopic expression of RPSAP52 increased MYBL2 expression in SCC‐4 cell. Finally, we illustrated that RPSAP52 overexpression promoted TSCC cell growth and cycle and induced cytokine secretion including IFN‐γ, IL‐1β and IL‐6, IL‐8, IL‐10 and TGF‐β via modulating MYBL2. These data provided new insight into RPSAP52, which may be one potential treatment target for TSCC.

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Knockdown of long non‑coding RNA prostate cancer‑associated transcript 1 inhibits the proliferation and metastasis of tongue squamous cell carcinoma cells by upregulating p21

Cited by 3 publications

References 27 publications

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

lncRNA RPSAP52 induced the development of tongue squamous cell carcinomas via miR‐423‐5p/MYBL2

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