2011
DOI: 10.1002/jcp.22502
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Knockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing

Abstract: Heme oxygenase (HO) represents an intrinsic cytoprotective system based on its anti-oxidative and anti-inflammatory properties mediated via its products biliverdin/bilirubin and carbon monoxide (CO). We showed that deletion of HO-2 results in impaired corneal wound healing with associated chronic inflammatory complications. This study was undertaken to examine the role of HO activity and the contribution of HO-1 and HO-2 to corneal wound healing in an in vitro epithelial scratch injury model. A scratch wound m… Show more

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Cited by 41 publications
(30 citation statements)
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References 48 publications
(91 reference statements)
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“…HO-2, for example, is a survival factor in the endothelium as shown by the observations that HO-2 deficiency exacerbates apoptosis of endothelial cells incurred by either glutamate or TNF-␣ (3,34), whereas increased amounts of HO-2 protein reduce the lethal effects of hypoxia in endothelial cells (18). Deficiency of HO-2 promotes the appearance of an activated phenotype in aortic endothelial cells (4), and following the wounding of the corneal epithelium, deficiency of HO-2 enhances inflammatory responses and impairs reparative responses (5,17). Exacerbation of inflammatory responses induced by the deficiency of HO-2 may thus contribute to the decreased AVF flow and increased AVF failure observed in HO-2-deficient mice.…”
Section: Discussionmentioning
confidence: 95%
“…HO-2, for example, is a survival factor in the endothelium as shown by the observations that HO-2 deficiency exacerbates apoptosis of endothelial cells incurred by either glutamate or TNF-␣ (3,34), whereas increased amounts of HO-2 protein reduce the lethal effects of hypoxia in endothelial cells (18). Deficiency of HO-2 promotes the appearance of an activated phenotype in aortic endothelial cells (4), and following the wounding of the corneal epithelium, deficiency of HO-2 enhances inflammatory responses and impairs reparative responses (5,17). Exacerbation of inflammatory responses induced by the deficiency of HO-2 may thus contribute to the decreased AVF flow and increased AVF failure observed in HO-2-deficient mice.…”
Section: Discussionmentioning
confidence: 95%
“…It is known that heme oxygenase promotes wound healing and migration of different cell types including epithelial cells migration [18,[22][23][24], and a recent study showed that Nrf2 knockout mice exhibited a delayed healing in the corneal epithelium [25]. Therefore, we examined whether DMF and carnosol could affect wound closure of ARPE cells using the scratch assay.…”
Section: Carnosol Stimulates Wound Closure In the Scratch Assaymentioning
confidence: 97%
“…6 Controlled amounts of carbon monoxide show a positive role in controlling cardiovascular and inflammatory impairment, in promoting wound healing, and bactericidal action. [7][8][9][10][11][12][13][14][15] Notably, the mode of action of CO in these beneficial roles is as-yet unresolved. However, that does not prevent exploitation of the positive behaviour of CO in medical applications.…”
Section: Introductionmentioning
confidence: 99%