Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway
Qian Cai,
Sirui Chen,
Yingqun Zhu
et al.
Abstract:Background: Chronic obstructive pulmonary disease (COPD) is a persistent chronic bronchitis disease, and its potential biomarkers have not been fully expounded. This study aims to explore the role of Guanine nucleotide binding protein like-3-like (GNL3L) in COPD induced by cigarette smoking (CS) in vivo. Methods: Two microarray datasets of COPD were selected to screen differentially expressed genes (DEGs). A protein-protein interaction network was constructed to find hub genes. The COPD model was conducted usi… Show more
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