Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway

Wang, Jianhong; Liu, Zhanyou; Wu, Li; Yu, Jialin; Zhang, Dongtao

doi:10.1016/j.meegid.2021.105158

Infection, Genetics and Evolution

2022

DOI: 10.1016/j.meegid.2021.105158

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Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway

Jianhong Wang

Zhanyou Liu

Li Wu

et al.

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2024

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Cited by 3 publications

References 29 publications

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Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Ruan,

Lyu,

Lai

et al. 2024

Interdisciplinary Medicine

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Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in Mycobacterium tuberculosis (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti‐TB therapies.

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Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Ruan,

Lyu,

Lai

et al. 2024

Interdisciplinary Medicine

View full text Add to dashboard Cite

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Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes

Ansari,

Singh,

Singh

et al. 2024

Tuberculosis

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Insights into the effect of guanylate-binding protein 1 on the survival of Brucella intracellularly

Li,

Wang,

Han

et al. 2024

Veterinary Microbiology

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Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway

Cited by 3 publications

References 29 publications

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection

Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes

Insights into the effect of guanylate-binding protein 1 on the survival of Brucella intracellularly

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