Knockdown of DANCR Suppressed the Biological Behaviors of Ovarian Cancer Cells Treated with Transforming Growth Factor-β (TGF-β) by Sponging MiR-214

Huang, Ping; Qi, Bingli; Yao, Hairong; Zhang, Liang; Li, Yanying; Li, Qian

doi:10.12659/msm.922760

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In ovarian cancer, lncRNA PVT1 promotes tumour growth and proliferation via the PVT1/miR-148a-3p/AGO1/TGF-β axis ( 117 ). In addition, DANCR is a sponge for miR-214, while KLF5 is a target of miR-214 ( 118 ). Silencing DANCR inhibits TGF-β-treated ovarian cancer cell viability, migration and invasion via the miR-214/KLF5 axis and induces apoptosis ( 118 ).…”

Section: Tgf-β Pathway-related Lncrnas and Other Cancer Typesmentioning

confidence: 99%

See 1 more Smart Citation

Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Liu

et al. 2023

Oncol Lett

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-β signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-β signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-β pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-β signalling pathway.

show abstract

Section: Tgf-β Pathway-related Lncrnas and Other Cancer Typesmentioning

confidence: 99%

“…In addition, DANCR is a sponge for miR-214, while KLF5 is a target of miR-214 ( 118 ). Silencing DANCR inhibits TGF-β-treated ovarian cancer cell viability, migration and invasion via the miR-214/KLF5 axis and induces apoptosis ( 118 ).…”

Section: Tgf-β Pathway-related Lncrnas and Other Cancer Typesmentioning

confidence: 99%

Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Liu

et al. 2023

Oncol Lett

View full text Add to dashboard Cite

show abstract

A review on the role of DANCR in the carcinogenesis

et al. 2022

View full text Add to dashboard Cite

DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a variety of miRNAs, including miR-874-3P, miR-335, miR-149, miR-4319, miR-758-3p, miR-216a-5p, miR-874-3p, miR-33a-5p, miR-335-5p, miR-145-3p, miR-665, miR-345-5p and miR-125b-5p. DANCR also regulates activity of PI3K/AKT/NF-κB, Wnt/β-catenin, ERK/SMAD, MAPK, IL-6/JAK1/STAT3, Smad2/3, p53, FAK/PI3K/AKT/GSK3β/Snail pathways. In the current narrative review article, we summarize the roles of DANCR in the carcinogenesis, with an especial emphasis on its role in the development of osteosarcoma and lung, liver, pancreatic and colorectal cancers.

show abstract

New evidence for a role of DANCR in cancers: a comprehensive review

Yuan,

Xu,

Zhang

et al. 2024

J Transl Med

View full text Add to dashboard Cite

Cancer remains a leading cause of mortality and poses a substantial threat to public health. Studies have revealed that Long noncoding RNA DANCR is a cytoplasmic lncRNA whose aberrant expression plays a pivotal role in various cancer types. Within tumour biology, DANCR exerts regulatory control over crucial processes such as proliferation, invasion, metastasis, angiogenesis, inflammatory responses, cellular energy metabolism reprogramming, and apoptosis. By acting as a competitive endogenous RNA for miRNAs and by interacting with proteins and mRNAs at the molecular level, DANCR contributes significantly to cancer progression. Elevated DANCR levels have also been linked to heightened resistance to anticancer drugs. Moreover, the detection of circulating DANCR holds promise as a valuable biomarker for aiding in the clinical differentiation of different cancer types. This article offers a comprehensive review and elucidation of the primary functions and molecular mechanisms through which DANCR influences tumours.

show abstract

Knockdown of DANCR Suppressed the Biological Behaviors of Ovarian Cancer Cells Treated with Transforming Growth Factor-β (TGF-β) by Sponging MiR-214

Cited by 5 publications

References 0 publications

Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

A review on the role of DANCR in the carcinogenesis

New evidence for a role of DANCR in cancers: a comprehensive review

Contact Info

Product

Resources

About