Knockdown of ATRX enhances radiosensitivity in glioblastoma
Yue Zhao,
Yifei Chen,
Ruoyu Liu
et al.
Abstract:Background
Glioblastoma are highly malignant type of primary brain tumors. Treatment for glioblastoma multiforme (GBM) generally involves surgery combined with chemotherapy and radiotherapy. However, the development of tumoral chemo- and radioresistance induces complexities in clinical practice. Multiple signaling pathways are known to be involved in radiation-induced cell survival. However, the role of alpha-thalassemia X-linked mutant retardation syndrome (ATRX), a chromatin remodeling protei… Show more
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