Knochenersatz

Rentsch, Claudia; Rentsch, Barbe; Scharnweber, Dieter; Zwipp, H.; Rammelt, Stefan

doi:10.1007/s00113-012-2238-4

Cited by 14 publications

(6 citation statements)

References 74 publications

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“…The majority of CaP bioceramics are chemically based on hydroxyapatite (HA), both types of tricalcium phosphate (α-TCP, ß-TCP) and/or their multiphase formulations (Dorozhkin, 2013). Calcium phosphate cements (CPCs) have been commercially available for years and are clinically applied as solids and cement pastes (Dorozhkin, 2008;Rentsch et al, 2012;Lodoso-Torrecilla et al, 2021). However, many CPCs, like most CaPs, have the disadvantage of incomplete degradation over months to years due to a low solubility under physiological conditions (Kurashina et al, 1997;Frakenburg et al, 1998;Bohner et al, 2003;Ambard and Mueninghoff, 2006;Kanter et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparison of degradation behavior and osseointegration of 3D powder-printed calcium magnesium phosphate cement scaffolds with alkaline or acid post-treatment

Kowalewicz

Waselau²,

Feichtner³

et al. 2022

Front. Bioeng. Biotechnol.

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Due to the positive effects of magnesium substitution on the mechanical properties and the degradation rate of the clinically well-established calcium phosphate cements (CPCs), calcium magnesium phosphate cements (CMPCs) are increasingly being researched as bone substitutes. A post-treatment alters the materials’ physical properties and chemical composition, reinforcing the structure and modifying the degradation rate. By alkaline post-treatment with diammonium hydrogen phosphate (DAHP, (NH4)2HPO4), the precipitation product struvite is formed, while post-treatment with an acidic phosphate solution [e.g., phosphoric acid (PA, H3PO4)] results in precipitation of newberyite and brushite. However, little research has yet been conducted on newberyite as a bone substitute and PA post-treatment of CMPCs has not been described in the accessible literature so far. Therefore, in the present study, the influence of an alkaline (DAHP) or acid (PA) post-treatment on the biocompatibility, degradation behavior, and osseointegration of cylindrical scaffolds (h = 5.1 mm, Ø = 4.2 mm) produced from the ceramic cement powder Ca0.75Mg2.25(PO4)2 by the advantageous manufacturing technique of three-dimensional (3D) powder printing was investigated in vivo. Scaffolds of the material groups Mg225d (DAHP post-treatment) and Mg225p (PA post-treatment) were implanted into the cancellous part of the lateral femoral condyles in rabbits. They were evaluated up to 24 weeks by regular clinical, X-ray, micro-computed tomographic (µCT), and histological examinations as well as scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) analysis and compared with tricalcium phosphate (TCP). All materials showed excellent biocompatibility and rapid osseointegration. While TCP degraded only slightly, the CMPCs showed almost complete degradation. Mg225d demonstrated significantly faster loss of form and demarcability from surrounding bone, scaffold volume reduction, and significantly greater degradation on the side towards the bone marrow than to the cortex than Mg225p. Simultaneously, numerous bone trabeculae have grown into the implantation site. While these were mostly located on the side towards the cortex in Mg225d, they were more evenly distributed in Mg225p and showed almost the same structural characteristics as physiological bone after 24 weeks in Mg225p. Based on these results, the acid post-treated 3D powder-printed Mg225p is a promising degradable bone substitute that should be further investigated.

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Section: Introductionmentioning

confidence: 99%

Comparison of degradation behavior and osseointegration of 3D powder-printed calcium magnesium phosphate cement scaffolds with alkaline or acid post-treatment

Kowalewicz

Waselau²,

Feichtner³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Allo-or xenografts carry the risk of immunogenic rejection and the potential for disease transmission [2,3]. Artificial matrix materials based on e.g., calcium phosphates, bioglass, synthetic or biological polymers and composites were developed to overcome the drawbacks of auto-, allo-and xenografts [4][5][6][7][8][9]. However, for bone regeneration, the ingrowth of osteogenic cells, as well as blood vessels to ensure sufficient nutrient and oxygen supply, is important.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Naturally Occurring Bioactive Factor Mixtures for Bone Regeneration

Bretschneider

Quade

Lode

et al. 2020

IJMS

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In this study, the bone-regenerative potential of bioactive factors derived from adipose tissue, platelet-rich plasma (PRP) and conditioned medium from hypoxia-treated human telomerase immortalized bone-marrow-derived mesenchymal stem cells (hTERT-MSC) was investigated in vitro with the aim to develop cost-effective and efficient bone substitutes for optimized regeneration of bone defects. Adipose tissue was harvested from human donors undergoing reconstructive surgery, and adipose tissue extract (ATE) was prepared. Platelet lysates (PL) were produced by repeated freeze-thaw cycles of PRP, and hypoxia-conditioned medium (HCM) was obtained by culturing human telomerase immortalized bone-marrow-derived mesenchymal stromal cells for 5 days with 1% O2. Besides analysis by cytokine and angiogenesis arrays, ELISA was performed. Angiogenic potential was investigated in cocultures of bone-marrow-derived (BM)-MSC and human umbilical vein endothelial cells. Multiple angiogenic proteins and cytokines were detected in all growth factor mixtures. HCM and ATE contained high amounts of angiogenin and CCL2/MCP-1, whereas PL contained high amounts of IGFBP-1. Culturing cells with HCM and ATE significantly increased specific ALP activity of BM-MSC as well as tubule length and junctions of endothelial networks, indicating osteogenic and angiogenic stimulation. To achieve a synergism between chemoattractive potential and osteogenic and angiogenic differentiation capacity, a combination of different growth factors appears promising for potential clinical applications.

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“…Bei allogenen Transplantaten werden diese Nachteile vermieden, müssen jedoch gegen die potenzielle Übertragung von Infektionskrankheiten – die allerdings als sehr gering eingeschätzt werden kann 5 – und der fehlenden „osteogenen Potenz“ gegenüber autologer Knochentransplantation abgewogen werden. Zum Risiko der Übertragung von HIV oder Hepatitis C gehen Schätzungen in der Literatur von einer Inzidenzrate bei Gewebespendern von 0,03% für HIV und 0,012% für Hepatitis C aus 6 .…”

Section: Introductionunclassified

Knochenaufbau und Knochenersatzmaterialien

Lang¹,

Klute²,

Rupp³

et al. 2022

Orthopädie und Unfallchirurgie up2date

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Knochendefekte können primär aus traumatologischen Ursachen sowie sekundär aus Knocheninfektionen und Tumorerkrankungen resultieren. Die chirurgische Wiederherstellung der Bewegungsorgane bei Vorliegen eines behandlungsbedürftigen Knochendefekts stellt trotz der Entwicklung diverser Verfahren zum Knochenersatz und Knochenaufbau auch heute noch eine Herausforderung dar. Das autologe Knochentransplantat gilt als Goldstandard in der Behandlung. Wachsende Bedeutung wird den synthetischen Knochenersatzmaterialien beigemessen.

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Knochenersatz

Cited by 14 publications

References 74 publications

Comparison of degradation behavior and osseointegration of 3D powder-printed calcium magnesium phosphate cement scaffolds with alkaline or acid post-treatment

Comparison of degradation behavior and osseointegration of 3D powder-printed calcium magnesium phosphate cement scaffolds with alkaline or acid post-treatment

Characterization of Naturally Occurring Bioactive Factor Mixtures for Bone Regeneration

Knochenaufbau und Knochenersatzmaterialien

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