Kniegelenk bei rheumatoider Arthritis – aktuelle orthopädisch-chirurgische Therapieoptionen

Maderbacher, Günther; Greimel, Felix; Schaumburger, Jens; Grifka, Joachim; Baier, Christel

doi:10.1007/s00393-018-0534-2

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…In contrast, RA manifests as a systemic disorder characterized by asymmetrical and erosive synovitis, affecting multiple joints across the body [4]. In no fewer than 65% of individuals diagnosed with RA, there exists an observed incidence of knee joint involvement [5]. Peripheral spondyloarthritis encompasses inflammatory conditions predominantly affecting joints outside the spine, encompassing entities such as ankylosing spondylitis, psoriatic arthritis, arthritis/spondylitis associated with inflammatory bowel disease, and reactive arthritis [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Schindler,

Puchner,

Reinhard

et al. 2024

JCM

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Background: Persistent knee synovitis leads to joint discomfort, incapacitating inflammation, and functional limitations. The conventional approach has involved surgical procedures to eliminate the actively inflamed synovial membrane. This study aims to investigate the recurrence-free survival and functional outcome after synovectomy and subsequent radiosynoviorthesis (RSO) in patients with knee synovitis. Methods: Thirty-seven knees diagnosed with pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), and peripheral spondyloarthritis underwent synovectomy and subsequent RSO between May 2005 and October 2016. The mean age was 34.9 ± 15.1 years, and the mean follow-up period was 84 ± 36.4 months. Clinical outcomes were assessed using the Oxford Knee Score and the presence of swelling and pain at the last follow-up. Recurrence-free survival denotes the duration from synovectomy to surgical re-synovectomy. Results: In general, twelve knees underwent re-synovectomy after a mean follow-up of 34.8 ± 24.9 months. The recurrence-free survival was 83.8% at two years, 71.3% at five years, and 61.7% at ten years. The subgroup analysis revealed recurrence-free survival at two years in 63.6% of patients with PVNS, 86.7% of those with RA, and 100% of individuals with peripheral spondyloarthritis. Conclusions: This study demonstrates that combined therapy for synovitis is an effective approach, significantly improving clinical outcomes.

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Section: Introductionmentioning

confidence: 99%

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Schindler,

Puchner,

Reinhard

et al. 2024

JCM

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“…Both OA and RA patients have comparable symptoms, including pain, swelling, and dysfunction around the joints [ 4 ]. Current therapies for OA and RA are similar, such as oral medications with nonsteroidal anti-inflammatory drugs [ 5 , 6 ], intra-articular injection with hormones and sodium hyaluronate [ 7 , 8 ], and surgical intervention for end-stage lesions [ 9 , 10 ]. However, the interventions are inadequate to impede the occurrence and progression of OA and RA.…”

Section: Introductionmentioning

confidence: 99%

Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis

Chen

et al. 2021

Hereditas

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Background Osteoarthritis (OA) and rheumatoid arthritis (RA) were two major joint diseases with similar clinical phenotypes. This study aimed to determine the mechanistic similarities and differences between OA and RA by integrated analysis of multiple gene expression data sets. Methods Microarray data sets of OA and RA were obtained from the Gene Expression Omnibus (GEO). By integrating multiple gene data sets, specific differentially expressed genes (DEGs) were identified. The Gene Ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and protein–protein interaction (PPI) network analysis of DEGs were conducted to determine hub genes and pathways. The “Cell Type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT)” algorithm was employed to evaluate the immune infiltration cells (IICs) profiles in OA and RA. Moreover, mouse models of RA and OA were established, and selected hub genes were verified in synovial tissues with quantitative polymerase chain reaction (qPCR). Results A total of 1116 DEGs were identified between OA and RA. GO functional enrichment analysis showed that DEGs were enriched in regulation of cell morphogenesis involved in differentiation, positive regulation of neuron differentiation, nuclear speck, RNA polymerase II transcription factor complex, protein serine/threonine kinase activity and proximal promoter sequence-specific DNA binding. KEGG pathway analysis showed that DEGs were enriched in EGFR tyrosine kinase inhibitor resistance, ubiquitin mediated proteolysis, FoxO signaling pathway and TGF-beta signaling pathway. Immune cell infiltration analysis identified 9 IICs with significantly different distributions between OA and RA samples. qPCR results showed that the expression levels of the hub genes (RPS6, RPS14, RPS25, RPL11, RPL27, SNRPE, EEF2 and RPL19) were significantly increased in OA samples compared to their counterparts in RA samples (P < 0.05). Conclusion This large-scale gene analyses provided new insights for disease-associated genes, molecular mechanisms as well as IICs profiles in OA and RA, which may offer a new direction for distinguishing diagnosis and treatment between OA and RA.

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Erkrankungen der Synovialmembran des Kniegelenkes: Entzündlich-rheumatische Erkrankungen

Gaulke¹

2023

Orthopädie Und Unfallchirurgie

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Kniegelenk bei rheumatoider Arthritis – aktuelle orthopädisch-chirurgische Therapieoptionen

Cited by 7 publications

References 23 publications

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis

Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis

Erkrankungen der Synovialmembran des Kniegelenkes: Entzündlich-rheumatische Erkrankungen

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