Knemometric Assessment of Short-Term Lower-Leg Growth in Children with Allergic Rhinitis (AR) treated with Fluticasone Furoate∗ (FF) Nasal Spray ∗USAN approved name

Gradman, Josefine; Caldwell, M; Wolthers, Ole D.

doi:10.1016/j.jaci.2006.12.560

Cited by 2 publications

(1 citation statement)

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“…INS can reduce growth only after they become available systemically. FF systemic bioavailability is low and it had no effect on lower-leg growth rate assessed by knemometry in children (Gradman et al 2007). …”

Section: Safety and Tolerabilitymentioning

confidence: 98%

Fluticasone furoate nasal spray in the treatment of allergic rhinitis

Giavina‐Bianchi¹

2008

TCRM

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Allergic rhinitis (AR) is a prevalent disease with great morbidity and signifi cant societal and economic burden. Intranasal corticosteroids are recommended as fi rst-line therapy for patients with moderate-to-severe disease, especially when nasal congestion is a major component of symptoms. To compare the effi cacy and safety profi le of different available intranasal corticosteroids for the treatment of AR, it is important to understand their different structures and pharmacokinetic and pharmacodynamic properties. Knowledge of these drugs has increased tremendously over the last decade. Studies have elucidated mechanisms of action, pharmacologic properties, and the clinical impact of these drugs in allergic respiratory diseases. Although the existing intranasal corticosteroids are already highly effi cient, the introduction of further improved formulations with a better effi cacy/ safety profi le is always desired. Fluticasone furoate nasal spray is a new topical corticosteroid, with enhanced-affi nity and a unique side-actuated delivery device. As it has high topical potency and low potential for systemic effects, it is a good candidate for rhinitis treatment.

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Section: Safety and Tolerabilitymentioning

confidence: 98%