Knee osteoarthritis grading by resonant Raman and surface-enhanced Raman scattering (SERS) analysis of synovial fluid

Bocşa, Corina; Moisoiu, Vlad; Ştefancu, Andrei; Leopold, Loredana; Leopold, Nicolae; Fodor, Daniela

doi:10.1016/j.nano.2019.04.015

Cited by 20 publications

(10 citation statements)

References 40 publications

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“…At the same time, effective protein removal techniques, including the trichloroacetic acid precipitation method, centrifugal method, and droplet deposition method, can effectively remove the influence of protein on Raman spectrum to observe HA more clearly. Bocsa et al [ 34 ] studied SF using resonance Raman technology combined with SERS. They found low carotenoid levels in advanced OA patients, and using a PCA–LDA analysis method to classify OA patients, they achieved an accuracy of 100%.…”

Section: Raman Spectroscopymentioning

confidence: 99%

“…As shown in Figure 1 , NIR/IR/Raman spectra of SF, articular cartilage, and/or subchondral bone were collected to compare the spectral differences between healthy and OA-affected joints. The spectra of SF indicate that the content of protein increased and the content of carotenoid decreased in OA-affected joints [ 34 ]. Furthermore, the spectra of articular cartilage characterized changes in the contents of GAG and PG, as well as the orientation of collagen fibers in joints [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

Chen

Zhao

et al. 2021

IJMS

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Osteoarthritis (OA) is a degenerative disease, and there is currently no effective medicine to cure it. Early prevention and treatment can effectively reduce the pain of OA patients and save costs. Therefore, it is necessary to diagnose OA at an early stage. There are various diagnostic methods for OA, but the methods applied to early diagnosis are limited. Ordinary optical diagnosis is confined to the surface, while laboratory tests, such as rheumatoid factor inspection and physical arthritis checks, are too trivial or time-consuming. Evidently, there is an urgent need to develop a rapid nondestructive detection method for the early diagnosis of OA. Vibrational spectroscopy is a rapid and nondestructive technique that has attracted much attention. In this review, near-infrared (NIR), infrared, (IR) and Raman spectroscopy were introduced to show their potential in early OA diagnosis. The basic principles were discussed first, and then the research progress to date was discussed, as well as its limitations and the direction of development. Finally, all methods were compared, and vibrational spectroscopy was demonstrated that it could be used as a promising tool for early OA diagnosis. This review provides theoretical support for the application and development of vibrational spectroscopy technology in OA diagnosis, providing a new strategy for the nondestructive and rapid diagnosis of arthritis and promoting the development and clinical application of a component-based molecular spectrum detection technology.

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Section: Raman Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

Chen

Zhao

et al. 2021

IJMS

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“…Other authors have examined human SF derived from knee OA patients, using combined SERS and resonant Raman spectra, being able to discriminate low-from high-grade groups with a classification accuracy of 100% [55].…”

Section: Synoviummentioning

confidence: 99%

Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy

Casal-Beiroa

González

Blanco

et al. 2020

Expert Review of Molecular Diagnostics

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Introduction: Osteoarthritis (OA) is a highly heterogenous disease influenced by different molecular, anatomic and physiologic imbalances. Some of the bottlenecks for enhanced diagnosis and therapeutic assessment are the lack of validated biomarkers and early diagnosis tools. In this narrative review, we analyze the potential of Raman spectroscopy (RS) as a label-free optical tool for the characterization of articular joint tissues and its application as a diagnosis tool for OA.Areas covered: Raman spectra produce a unique "molecular fingerprint" providing rotational and vibrational molecular information, allowing the identification and follow-up of molecular changes associated with OA pathological mechanisms. Focusing on multiple joint tissues (cartilage, synovium, bone, tendons, ligaments and meniscus) and their contribution in disease incidence and progression, this review highlights the current knowledge on the application of RS in the characterization of organic and inorganic molecules present at these tissues and alterations that occur in the onset of OA.Expert Opinion: Vibrational spectroscopy techniques, such as RS, are low cost, rapid and minimally invasive approaches that offer high specificity in the assessment of the molecular composition of complex tissues. Combined with multivariate statistical methods, RS offers great potential for optical biomarkers discovery or disease diagnosis applications, and we hereby discuss clinical translational progresses on the field.

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“…It has been extensively studied in the field of tissue engineering, including as a cell growth scaffold to promote bone tissue regeneration and as a transplant material for repairing peripheral nerves [6,7]. Nanomaterials can perform biological imaging through spectral and fluorescent signals to promote disease diagnosis [8]. At the same time, nanomaterials can also be used as biosensors to effectively monitor disease progression [9].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

Liu

Zhang

Wang

2021

Journal of Nanomaterials

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Osteoarthritis (OA) is a bone and joint disease with pathological characteristics such as articular cartilage degeneration injury and synovial and subchondral bone reactive hyperplasia. Once cartilage is damaged, it is difficult to repair it by itself. Current clinical practice is mainly limited to symptomatic treatment, not changing the degenerative process of osteoarthritis. The important goal of nanomedicine is targeted delivery. Nanoparticles (NPs) can provide many unique potential functions for the targeted treatment of arthritis. This review summarizes the research progress of nanomaterials as a drug delivery system in the treatment of osteoarthritis from three aspects: (1) the etiology of OA and the current research status of applying nanoparticles to treat OA, (2) the construction of osteoarthritis models, and (3) the classification of nanoparticle-based drug delivery systems.

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Knee osteoarthritis grading by resonant Raman and surface-enhanced Raman scattering (SERS) analysis of synovial fluid

Cited by 20 publications

References 40 publications

Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

Vibrational Spectroscopy in Assessment of Early Osteoarthritis—A Narrative Review

Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy

Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

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