Knee osteoarthritis and metabolic syndrome

Hamad, W. Haj; Maraoui, M; Sghir, M.; Guedria, Mohamed; Said, Wafa; Jerbi, Saïda; Kessomtini, W.

doi:10.1016/j.rehab.2016.07.353

Cited by 5 publications

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“…Also, we found no difference between the two groups when the subjects are allocated to categories according to the level of handicap. In contrast to our results, other studies [ 26 , 27 ] have found a positive correlation between MetS and Lequesne index score. Hewala et al [ 26 ] described that MetS was significantly more present in subjects with very severe and extremely severe handicaps according to the Lequesne index score.…”

Section: Discussioncontrasting

confidence: 99%

Association Between Metabolic Syndrome, Its Components, and Knee Osteoarthritis in Premenopausal and Menopausal Women: A Pilot Study

Nemet¹,

Blazin²,

Milutinovic³

et al. 2022

Cureus

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Objective: This pilot study aimed to determine the correlation of metabolic syndrome (MetS), its components, and increased LDL (low-density lipoprotein) and total cholesterol levels with osteoarthritis (OA). In addition, our goal was to establish the association between MetS and the degree of handicap measured by the Lequesne index of functionality and severity of knee osteoarthritis.Materials and methods: The pilot study included 25 subjects with knee OA and 19 subjects without knee OA. All subjects were menopausal or premenopausal women. MetS was diagnosed according to the National Cholesterol Education Program, Adult Treatment Panel III. OA was diagnosed if Kellgren-Lawrence ≥ 2.Results: MetS was detected in 80% of subjects with OA. In the non-OA group, MetS was detected in 26% of subjects. The difference in MetS prevalence between the two groups was significant (p=0.000). The presence of each MetS component was significant in the OA group, except for central obesity, which presence was marginally significant (p=0.054). Prevalence of increased total (p=0.019) and LDL cholesterol (p=0.000) was also significant in the OA group. A significant difference between OA and the non-OA group was detected in the prevalence of all five MetS components (p=0.016). In the OA group, the Lequesne index of functionality and severity of knee osteoarthritis was not significantly altered between subjects with and without MetS. Conclusion: Metabolic syndrome, its components, increased LDL, and total cholesterol are correlated with osteoarthritis in premenopausal and menopausal women. MetS is not correlated with the degree of handicap in the knee joint measured by the Lequesne index.

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Section: Discussioncontrasting

confidence: 99%

Association Between Metabolic Syndrome, Its Components, and Knee Osteoarthritis in Premenopausal and Menopausal Women: A Pilot Study

Nemet¹,

Blazin²,

Milutinovic³

et al. 2022

Cureus

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“…Additionally, cholesterol accumulation in the cartilage can impair the efflux function of cartilage, hence inducing OA. [ 39 , 40 ]…”

Section: Discussionmentioning

confidence: 99%

Association between hypertension and risk of knee osteoarthritis

2017

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Evidence from observational studies shows that hypertension may be a risk factor for knee osteoarthritis (OA). However, the relationship between hypertension and knee OA risk remains controversial. This study aimed to quantitatively assess the relationship between hypertension and risk of knee OA.Three electronic databases (PubMed, Embase, and Cochrane Library) were searched up to July 25, 2016. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were extracted from the included observational studies. Publication bias, heterogeneity test, and subgroup analyses were performed.Eight studies including 2 cohort studies and 6 cross-sectional studies with 9762 participants were finally included in this meta-analysis. The results showed that hypertension was significantly associated with higher radiographic knee OA and symptomatic knee OA risks of 2.01 (95% CI, 1.28–3.15, I2 = 90.2%, P for heterogeneity <.001) and 1.49 (95% CI, 1.26–1.77, I2 = 0%, P for heterogeneity <.412), respectively. No publication bias was detected. The subgroup analysis showed that the study design did not influence the results (radiographic knee OA: OR = 1.42, 95% CI, 1.19–1.71 for cross-sectional studies and OR = 2.17, 95% CI, 1.30–3.63 for cohort studies; and symptomatic knee OA: OR = 1.85, 95% CI, 1.10–3.13) for cross-sectional studies and OR = 2.74, 95% CI, 1.81–4.16 for cohort studies).This meta-analysis showed that there was a significant relationship between hypertension and knee OA (both radiographic and symptomatic). However, further original studies are needed that use a better design.

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“…A prospective study found that the prevalence of MetS among KOA patients was 53.1% [37]. Another evidence for the association between MetS and KOA comes from the study of Yoshimura et al [38], who found elevated risk for development and progression of KOA over a 3-years period associated with increased number of MetS components.…”

Section: Ekim Et Al Also Divided the Koa Patientsmentioning

confidence: 99%

“…Hamad et al [37] found that 32% of the KOA patients were diabetic, 44.9% were hypertensive and 24.5% had dyslipidemia.…”

Section: Ekim Et Al Also Divided the Koa Patientsmentioning

confidence: 99%

Assessment of Carotid Atherosclerosis in Patients with Knee Osteoarthritis

et al. 2022

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Background: Atherosclerosis is a highly prevalent chronic disorder that substantially impacts quality of life and leads to significant morbidity and mortality. Atherosclerosis is an important feature associated with increased cardiometabolic risk. Several factors may account for relationship between Knee osteoarthritis (KOA) and cardiovascular diseases (CVD) Aim:The aim of this study is to assess the association between the severity of KOA and carotid atherosclerosis. Subjects and Methods:A total of 100 consecutive patients with primary symptomatic KOA were invited to participate in this study. Patients were recruited from the Outpatient Rheumatology Clinic at Mansoura University Hospitals. The study included also 100 consecutive non-KOA subjects matched for age, sex and BMI with KOA patients. All patients met the 2010 EULAR criteria for diagnosis of KOA and patients had to show evidence of radiological changes of KOA by plain radiography and Knee Ultrasonography. Blood samples were collected from all participants to test for ESR, CRP, fasting blood sugar and lipid profile. Assessment of carotid atherosclerosis is made by measurements of Carotid intima media thickness (cIMT). Results:Comparison between KOA group and non-KOA group. The mean Waist hip ratio was significantly higher in KOA group than non-KOA group (p<0.001). KOA patients had significantly more frequent HTN (p=0.034), T2DM (p=0.025) and Met syndrome (p=0.002). The mean FBS level, serum total cholesterol level of the KOA group was significantly higher than non-KOA group (p=0.021, p=0.039). KOA group had higher cIMT the non-KOA group (p=0.003) and more frequently had carotid plaques that non-KOA group (p=0.005). the rate of presence of HTN, T2DM and MetS differed significantly among the KOA subgroups (p=0.032, p=0.013 and p=0.020 respectively) with the KOA-KL4 subgroup had the highest rate of the three co-morbidities. The cIMT differed significantly among the KOA subgroups based on KL grading being thickest in the KOA-KL4 subgroup of patients (p<0.001). The rate of presence of carotid plaques differed among the groups, with rate being highest in KOA-KL4 subgroup (79.2%), followed by KOA-KL3 subgroup (35.7%) and is lowest in KOA-KL2 subgroup (8.3%). These differences were significant (p<0.001). Conclusion:Carotid Atherosclerosis is associated with KOA, therefore, a diagnosis of OA may serve as a red flag for warning to evaluate CVD. The presence of the MetS, serum TC, radiological KL grade and higher US cartilage thickness grading were the strongest factors that predict the higher cIMT and higher prevalence of carotid plaques in patients with KOA. The presence of the MetS, serum TC and radiological KL grade were the strongest factors that predict the higher cIMT in patients with KOA (p=0.026, p=0.006, p=0.004 and p=0.015 respectively)

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Knee osteoarthritis and metabolic syndrome

Cited by 5 publications

References 0 publications

Association Between Metabolic Syndrome, Its Components, and Knee Osteoarthritis in Premenopausal and Menopausal Women: A Pilot Study

Association Between Metabolic Syndrome, Its Components, and Knee Osteoarthritis in Premenopausal and Menopausal Women: A Pilot Study

Association between hypertension and risk of knee osteoarthritis

Assessment of Carotid Atherosclerosis in Patients with Knee Osteoarthritis

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