Knee osteoarthritis and body mass index: a population‐based case–control study

Holmberg, Sara; Thelin, Anders; Thelin, Nils

doi:10.1080/03009740510017922

Cited by 95 publications

(74 citation statements)

References 23 publications

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“…Of note, while those in the highest BMI categories had a greater risk than those in the lowest categories, no threshold effect was found, which suggests that even modest to moderate levels of overweight-less than conventional definitions of obesity-convey increased risk. Even within the normal weight range of BMI <25 kg/m 2 , moderate increases in BMI have been shown to be significantly related to knee OA [46], which suggests that even modest levels of increasing weight convey an increased risk of knee OA.…”

Section: Osteoarthritismentioning

confidence: 99%

“…The evidence is strong enough that the American College of Rheumatology OA treatment guidelines recommend weight loss for overweight persons with knee OA [42]. Obesity has been shown to be strongly associated with knee OA across race/ethnicity and sex [43][44][45], although some conflicting evidence about the relative strength of the association in males versus females exists [46]. Analyses conducted on the National Health and Nutrition Examination Survey (NHANES) data show that adults in the United States with a BMI ≥30 kg/m 2 have a >4-fold higher prevalence of radiographic knee OA than those with a BMI <30 kg/m 2 [47].…”

Section: Osteoarthritismentioning

confidence: 99%

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Overview of the relationship between pain and obesity: What do we know? Where do we go next?

Janke¹,

Collins²,

Kozak³

2007

JRRD

183

141

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Abstract-Overweight/obesity and pain are significant problems of increasing prevalence; understanding the relationship between the two is the focus of a growing body of research. Findings from this review support a likely relationship between increasing weight and pain conditions such as osteoarthritis and low back pain. Longitudinal studies suggest overweight/obesity early in life is a risk factor for pain, and the co-occurrence of pain and overweight/obesity negatively affects quality of life. The mechanism of relationship is unknown but is hypothesized to include mechanical and metabolic abnormalities, possibly secondary to lifestyle choices. Observations from a few studies demonstrate that treatments for obesity reduce pain secondary to weight loss. Few studies examine both pain and weight as primary outcomes, and variability in measurement makes comparisons and conclusions difficult. Research should focus on expanding knowledge about mechanisms of the relationship between pain and obesity, testing explanatory models addressing their co-occurrence, and developing treatments that most effectively target this comorbidity.

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Section: Osteoarthritismentioning

confidence: 99%

Section: Osteoarthritismentioning

confidence: 99%

Overview of the relationship between pain and obesity: What do we know? Where do we go next?

Janke¹,

Collins²,

Kozak³

2007

JRRD

183

141

View full text Add to dashboard Cite

show abstract

“…6,7 Weight, even in the upper tertile of normal range (body mass index (BMI) 22-o25 kg/m 2 ) is associated with an increased risk of developing medial compartment and patellofemoral knee OA, 8,9 suggesting a dose response effect of weight on the incidence of knee OA. Biomechanics may explain part of the contribution of weight to knee OA.…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

et al. 2006

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Objective: To determine the point prevalence of painful musculoskeletal (MSK) conditions in obese subjects before and after weight loss following bariatric surgery. Design: Longitudinal, interventional, unblended. Subjects: Forty-eight obese subjects (47 women, one man, mean age 4479 years; mean body mass index (BMI) 5178 kg/m 2 ) recruited from an academic medical center bariatric surgery program. Measurements: Comorbid medical conditions; MSK findings; BMI; Western Ontario McMaster Osteoarthritis Index (WOMAC) for pain, stiffness and function; and SF-36 s for quality of life. Methods: Consecutive subjects were recruited from the University Hospitals of Cleveland Bariatric Surgery Program. Musculoskeletal signs and symptoms and non-MSK comorbid conditions were documented at baseline and at follow-up. Subjects completed the SF-36 s and the WOMAC questionnaires. Analyses were carried out for each MSK site, fibromyalgia syndrome (FMS) and for the cumulative effect on the spine, upper and lower extremities. The impact of change in comorbid medical conditions, BMI, physical and mental health domains of the SF-36 s on the WOMAC pain subscale score was evaluated. SF-36 s outcomes were compared to normal published controls. Results: Forty-eight subjects were available for baseline and a follow-up assessment 6-12 months after gastric bypass surgery. They lost an average of 41715 kg and the mean BMI decreased from 5178 to 3677 kg/m 2 . Baseline comorbid medical conditions were present in 96% before surgery and 23% after weight loss. There was an increased prevalence of painful MSK conditions at baseline compared to general population frequencies. Musculoskeletal complaints had been present in 100% of obese subjects before, and 23% after weight loss. The greatest improvements occurred in the cervical and lumbar spine, the foot and in FMS (decreased by 90, 83, 83 and 92%, respectively). Seventy-nine percent had upper extremity MSK conditions before and 40% after weight loss. Before surgery, 100% had lower extremity MSK conditions and only 37% did after weight loss. The WOMAC subscale and composite scores all improved significantly, as did the SF-36 s . Change in BMI was the main factor impacting the WOMAC pain score. Conclusion: There was a higher frequency of multiple MSK complaints, including non-weight-bearing sites compared to historical controls, before surgery, which decreased significantly at most sites following weight loss and physical activity. These benefits may improve further, as weight loss may continue for up to 24 months. The benefits seen with weight loss indicate that prevention and treatment of obesity can improve MSK health and function.

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“…There were no underweight subjects in the present study. Previous studies have also shown that knee OA is more frequent in women and obese people [4,6]. The subjects were classified into five classes of the SD height-weight classification (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Relations between some anthropometric parameters of knee osteoarthritic patients and some indicators of the disease

Übner

Õun

Mägi

2013

PoA

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Knee osteoarthritis (OA) is related to the person's gender, weight and age. However, associations between the body types and disease related values are not clear. All the subjects participated in the study of a new mud therapy course in Estonian medical spas and had knee OA. The mean age of the subjects was 61.7 years (62.0 years for women and 61.1 years for men). Based on the 5 SD heightweight classification, devised by the Centre for Physical Anthropology at the University of Tartu, the subjects were divided into five classes (1 -small height and weight; 2 -medium height and weight; 3 -big weight and height; 4 -big weight, small height; 5 -small weight, big height). The results showed that knee OA was more prevalent in women than men. 39.8% of the subjects were obese. Leptomorphic females and males prevailed among the subjects (28.5% and 26.8%, accordingly). Therefore, the height is also one factor which is associated with knee OA. Females had more problems with their knees than males. The group of small females had more problems with both knees, but pycnomorphic females complained more about knee pain in the last month before the study. Therefore, they used more analgesics. In both genders, the more problematic knee was the right knee. The class of medium males also had more problems with both knees. They had the highest values of the morning stiffness of the knee and knees crepitus in active motion.

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Knee osteoarthritis and body mass index: a population‐based case–control study

Abstract: A moderate increase in BMI, within the normal weight range, was significantly related to knee osteoarthritis among men. Overweight at any time was related to knee osteoarthritis.

Cited by 95 publications

References 23 publications

Overview of the relationship between pain and obesity: What do we know? Where do we go next?

Overview of the relationship between pain and obesity: What do we know? Where do we go next?

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

Relations between some anthropometric parameters of knee osteoarthritic patients and some indicators of the disease

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