Abstract:Bone is a dynamic tissue that is constantly remodeling. However, for individuals requiring bed rest or astronauts exposed to microgravity in space, a lack of normal loaded activities leads to disuse osteoporosis. We examined whether knee loading increases bone mineral d e ns i t y (B M D) of b ot h c o nt r o l a n d t a ilsuspended hindlimbs. We also examined whether the phosphorylation levels of Akt in phosphoinositide 3-kinase (PI3K) signaling and eukaryotic initiation factor 2α (eIF2α) in an integrated str… Show more
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