Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations

Zeighami, Ali; Dumas, Raphaël; Aïssaoui, Rachid

doi:10.1038/s41598-021-87978-2

Cited by 18 publications

(16 citation statements)

References 61 publications

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“…It is well known that biomechanical factors such as excessive or frequent loading, misplaced contact regions, and altered muscle loading are associated with impaired medial-to-lateral load distribution and correlates with regional cartilage changes in KOA. − Our findings were supported by previous studies that the overall condition of the cartilage in the M-A compartment of the tibial plateau was worse than in the L-A region of the tibial plateau. Thus, this may indicate that the cartilage degeneration expands from the anterior to the posterior in the medial tibial plateau to the lateral tibial plateau.…”

Section: Resultssupporting

confidence: 84%

High-Resolution N-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis

et al. 2023

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N-glycan alterations contribute to the progression of several joint diseases, including knee osteoarthritis (KOA). However, molecular changes in KOA subchondral trabecular bone, when exposed to different joint loading forces, are still unknown. The aim of this study was, therefore, to demonstrate the feasibility to differentiate Nglycan changes in subchondral trabecular bone from four different joint loading forces of the tibial plateau regions (i.e., Lateral Anterior (L-A), Lateral Posterior (L-P), Medial Anterior (M-A), and Medial Posterior (M-P)) in KOA patients (n = 10) using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) at 20 μm spatial resolution. The degree of cartilage degeneration was evaluated histologically, and the subchondral bone tissue microarrays (TMAs) were subsequently manually constructed from formalin-fixed paraffin-embedded (FFPE) KOA osteochondral (i.e., cartilagesubchondral bone) tissues. Overall, the Osteoarthritis Research Society International (OARSI) histological grade was significantly higher and the size of chondrocytes in the superficial zone was much larger for both M-A and M-P compared to L-A and L-P of cartilage (p = 0.006, p = 0.030, p = 0.028, and p = 0.010; respectively). Among the 65 putative N-glycans observed by MALDI-MSI, 2 core fucosylated bi-antennary N-glycans, m/z 1809.64; (Hex) 5 (HexNAc) 4 (Fuc) 1 and 2100.73; (NeuAc) 1 (Hex) 5 (HexNAc) 4 (Fuc) 1 , were significantly higher in intensity in M-A compared to L-A of the trabecular bone (p = 0.027, and p = 0.038, respectively). These N-glycans were then further structurally characterized by in situ MS/MS fragmentation post-MALDI-MSI. Our results demonstrate, for the first time, N-glycan alterations can occur at different joint loading forces in the KOA tibial plateau and the feasibility of subchondral bone TMA construction for N-glycan MALDI-MSI.

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Section: Resultssupporting

confidence: 84%

High-Resolution N-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis

et al. 2023

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“…The effect of gait modifications on latKCF has not been investigated in the past. Previous studies found KFM or KEM as the main contributor to latKCF 41 , suggesting that offloading gait should target these parameters. 36 , 39 However, this presumption need to be validated in an experimental study.…”

Section: Discussionmentioning

confidence: 92%

Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment

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Drongelen

Uhlrich

et al. 2023

Sci Rep

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Compressive knee joint contact force during walking is thought to be related to initiation and progression of knee osteoarthritis. However, joint loading is often evaluated with surrogate measures, like the external knee adduction moment, due to the complexity of computing joint contact forces. Statistical models have shown promising correlations between medial knee joint contact forces and knee adduction moments in particularly in individuals with knee osteoarthritis or after total knee replacements (R2 = 0.44–0.60). The purpose of this study was to evaluate how accurately model-based predictions of peak medial and lateral knee joint contact forces during walking could be estimated by linear mixed-effects models including joint moments for children and adolescents with and without valgus malalignment. Peak knee joint moments were strongly correlated (R2 > 0.85, p < 0.001) with both peak medial and lateral knee joint contact forces. The knee flexion and adduction moments were significant covariates in the models, strengthening the understanding of the statistical relationship between both moments and medial and lateral knee joint contact forces. In the future, these models could be used to evaluate peak knee joint contact forces from musculoskeletal simulations using peak joint moments from motion capture software, obviating the need for time-consuming musculoskeletal simulations.

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“…The effect of gait modi cations on latKCF has not been investigated in the past. Previous studies found KFM or KEM as the main contributor to latKCF 35 , suggesting that o oading gait should target these parameters. 31,33 All four statistical models from the present study revealed a negatively directed correlation between KAM and latKCF.…”

Section: Discussionmentioning

confidence: 95%

Knee Joint Moments Can Accurately Predict Medial and Lateral Knee Contact Forces in Patients With Valgus Malalignment

Holder

Drongelen

Uhlrich

et al. 2022

Preprint

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Compressive knee joint contact force during walking is thought to be related to initiation and progression of knee osteoarthritis. However, joint loading is often evaluated with surrogate measures, like the external knee adduction moment, due to the complexity of computing joint contact forces. Statistical models have shown promise for predicting joint contact force from easily measured joint moments in individuals with osteoarthritis or joint replacements. This approach may also be effective in young patients with valgus deformities. The purpose of this study was to evaluate how accurately medial and lateral knee joint contact forces could be estimated by linear mixed-effects models during walking for children with and without valgus malalignment. Knee joint moments were strongly correlated (R2 > 0.85, p < 0.001) with both medial and lateral knee joint contact forces. The knee flexion and adduction moments were significant covariates in most of the models, strengthening the understanding of the contribution of both moments to medial and lateral knee joint contact force. In the future, these models could be used to predict knee joint contact forces using joint moments from motion capture software, obviating the need for time-consuming musculoskeletal simulations.

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Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations

Cited by 18 publications

References 61 publications

High-Resolution N-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis

High-Resolution N-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis

Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment

Knee Joint Moments Can Accurately Predict Medial and Lateral Knee Contact Forces in Patients With Valgus Malalignment

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