Knee Laxity in Patients With Osteoarthrttis and Rheumatoid Arthritis

Wada, Makoto; Imura, Satoru; Baba, H.; Shimada, Seiichiro

doi:10.1093/rheumatology/35.6.560

Cited by 97 publications

(90 citation statements)

References 13 publications

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“…Furthermore, joint instability is a major risk factor in the development of OA (1,2), and it has been shown in human studies that AP laxity is elevated in early-stage OA (11). Although the relationship between ligament laxity and joint laxity has not been defined, due to the precise nature of the joint a small alteration would have large consequences: "a little laxity is a lot" (42).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in order to study the pathogenesis of secondary OA, investigators in many experimental studies have induced knee instability by ligament weakening or transection (7,8). In addition, several studies, in both humans and animal models of OA, have demonstrated a correlation between the extent of cruciate ligament damage or laxity and the severity of OA features such as cartilage loss and osteophyte formation (4,(8)(9)(10)(11).…”

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confidence: 99%

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Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Quasnichka¹,

Anderson-MacKenzie²,

Tarlton³

et al. 2005

Arthritis & Rheumatism

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Objective. The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary OA. Additionally, femoral notch narrowing at the anterior cruciate ligament (ACL) insertion site is associated with disease severity, but it is unknown whether ligament deterioration precedes or follows osteophyte formation. We examined cruciate ligament mechanics and metabolism and the intercondylar notch width in OAprone Dunkin-Hartley (DH) guinea pigs at ages up to and including the age at OA onset (24 weeks), and compared the data with those in age-matched controls (Bristol strain 2 [BS2] guinea pigs).Methods. Guinea pigs were assessed at 3, 6, 9, 12, 16, 20, 24, and 36 weeks of age. ACLs were mechanically tested, and the intercondylar notch width index (NWI) was determined. Cruciate ligament metabolism was determined by measuring the following markers of collagen turnover: matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 2, C-terminal type I procollagen propeptide (PICP), and the immature collagen-derived crosslink dihydroxylysinonorleucine (DHLNL).Results. DH guinea pigs had significantly laxer ACLs than did BS2 guinea pigs, at 12, 16, and 24 weeks. We observed elevated levels of pro and active MMP-2, PICP, and DHLNL in the cruciate ligaments of DH animals at most ages, compared with BS2 guinea pigs. The NWI in DH animals was significantly lower than that in BS2 guinea pigs at 24 and 36 weeks.Conclusion. In DH guinea pigs, laxer ACLs, which are associated with increased collagen turnover, may cause joint instability and predispose these animals to the early onset of OA. Decreased intercondylar notch width in the DH animals indicates that bone remodeling at the ACL insertion site is a response to elevated ACL laxity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Quasnichka¹,

Anderson-MacKenzie²,

Tarlton³

et al. 2005

Arthritis & Rheumatism

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“…Frontal plane (varus-valgus) laxity has never been found to be associated with self-reported knee instability (3,4,6,13). Because episodes of knee instability might mainly represent movements in the sagittal plane, sagittal plane laxity (17,45,46) could be more strongly related to self-reported knee instability, compared to frontal plane laxity. Unfortunately, no study has focused on the relationship between sagittal laxity and knee instability.…”

Section: Knoop Et Almentioning

confidence: 99%

Association of lower muscle strength with self‐reported knee instability in osteoarthritis of the knee: Results from the Amsterdam Osteoarthritis Cohort

Knoop¹,

Leeden²,

Esch³

et al. 2011

Arthritis Care & Research

106

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Objective. To determine whether muscle strength, proprioceptive accuracy, and laxity are associated with self-reported knee instability in a large cohort of knee osteoarthritis (OA) patients, and to investigate whether muscle strength may compensate for impairment in proprioceptive accuracy or laxity, in order to maintain knee stability. Methods. Data from 283 knee OA patients from the Amsterdam Osteoarthritis cohort were used. Univariable and multivariable logistic regression analyses were performed to assess the association between muscle strength, proprioceptive accuracy (motion sense), frontal plane varus-valgus laxity, and self-reported knee instability. Additionally, effect modification between muscle strength and proprioceptive accuracy and between muscle strength and laxity was determined. Results. Self-reported knee instability was present in 67% of the knee OA patients and mainly occurred during walking. Lower muscle strength was significantly associated with the presence of self-reported knee instability, even after adjusting for relevant confounding. Impaired proprioceptive accuracy and high laxity were not associated with self-reported knee instability. No effect modification between muscle strength and proprioceptive accuracy or laxity was found. Conclusion. Lower muscle strength is strongly associated with self-reported knee instability in knee OA patients, while impairments in proprioceptive accuracy and laxity are not. A compensatory role of muscle strength for impaired proprioceptive accuracy or high laxity, in order to stabilize the knee, could not be demonstrated.

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“…The latter does not allow for an objective assessment but, to the authors' knowledge, results of instrumented measurements have never been reported in such injuries. Finally, as knee osteoarthritis affects rotational knee laxity [88], rotational knee laxity measurements may also have the potential to be an indicator of the type and severity of osteoarthritis.…”

Section: Further Considerations For Diagnosismentioning

confidence: 99%

Objective measurements of static anterior and rotational knee laxity

Mouton

Theisen

Seil

2016

Curr Rev Musculoskelet Med

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Several devices allow to measure anterior and rotational static knee laxity. To date, the use of rotational laxity measurements in the daily clinical practice however remains to be improved. These measurements may be systematically integrated to the follow-up of knee injuries. Physiologic laxity measurements may particularly be of interest for the identification of risk factors in athletes. Furthermore, knee laxity measurements help to improve the diagnosis of knee soft tissue injuries and to follow up reconstructions. Further prospective follow-ups of knee laxity in the injured/reconstructed knees are however required to conclude on the best treatment strategy for knee soft tissue injuries.

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Knee Laxity in Patients With Osteoarthrttis and Rheumatoid Arthritis

Cited by 97 publications

References 13 publications

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Association of lower muscle strength with self‐reported knee instability in osteoarthritis of the knee: Results from the Amsterdam Osteoarthritis Cohort

Objective measurements of static anterior and rotational knee laxity

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