Knee Joint Pain Potentially Due to Bone Alterations in a Knee Osteoarthritis Patient

Komatsu, Masatoshi; Nakamura, Yukio; Kamimura, Mikio; Uchiyama, Shigeharu; Mukaiyama, Keijiro; Ikegami, Shota; Kato, Hiroyuki

doi:10.12659/ajcr.891233

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…In support of this, patients with hip OA and continuous joint pain showed persistent bone signal changes in MRI, while those in whom the pain had disappeared exhibited an absence of signal changes [23] . Similar findings have been described for knee OA [9] . Accordingly, we suspect that MRI bone signal changes also disappear over time along with the resolution of joint pain in forefoot OA.…”

Section: Casesupporting

confidence: 89%

“…Based on our observations, we earlier proposed that the major pathophysiology of hip, shoulder, and knee OA with accompanying joint pain may be due to bone alterations [6][7][8][9] . While we often encounter patients without serious radiographic OA complaining of joint pain, even in the small joints, there are also numerous cases of advanced radiographic OA with no pain in the affected bone regions.…”

Section: Introductionmentioning

confidence: 69%

“…Based on the results of our previous studies [6][7][8][9] and others [20] , we consider that bone signal changes detected by MRI may be representative of microfractures, which in turn cause joint pain. In support of this, patients with hip OA and continuous joint pain showed persistent bone signal changes in MRI, while those in whom the pain had disappeared exhibited an absence of signal changes [23] .…”

Section: Casementioning

confidence: 90%

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Osteoarthritis in the forefoot accompanied with joint pain is potentially associated with bone alterations

Nakamura

Kamimura²,

Uchiyama³

et al. 2015

IJDI

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Section: Casesupporting

confidence: 89%

Section: Introductionmentioning

confidence: 69%

Section: Casementioning

confidence: 90%

See 1 more Smart Citation

Osteoarthritis in the forefoot accompanied with joint pain is potentially associated with bone alterations

Nakamura

Kamimura²,

Uchiyama³

et al. 2015

IJDI

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“…Although many underlying mechanisms, such as bone alterations, contribute to OA-induced pain [ 4 ], inflammation is now believed to play an important role in the pathogenesis of OA-induced pain [ 5 ]. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine produced by macrophages within innate and adaptive immune responses [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Synovial Fluid Macrophage Migration Inhibitory Factor Levels Correlate with Severity of Self-Reported Pain in Knee Osteoarthritis Patients

Zhang

Liu

et al. 2016

Med Sci Monit

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BackgroundInflammation is considered as one of the main pathogeneses in OA-induced pain. Macrophage migration inhibitory factor (MIF) is a well known pro-inflammatory cytokine. We aimed to determine whether MIF levels in serum and synovial fluid (SF) are associated with severity of OA-induced pain.Material/MethodsWe recruited 226 patients with knee OA and 106 controls. Self-reported pain severity of OA patients was evaluated using the Western Ontario McMaster University Osteoarthritis (WOMAC) pain scores. MIF levels were detected using enzyme-linked immunosorbent assay (ELISA).ResultsOA patients had similar serum MIF levels compared to controls (11.93 [5.68–18.10] vs. 10.06 [6.60–14.61] ng/ml, P>0.05). In OA patients, MIF levels in SF were dramatically lower compared to paired serum samples (3.39 [1.87–5.89] vs. 11.93 [5.68–18.10] ng/ml, P<0.01). MIF levels in SF were significantly correlated with WOMAC pain scores (r=0.237, P<0.001), but MIF levels in serum had no significant correlation with WOMAC pain scores (r=0.009, P=0.898).ConclusionsMIF levels in SF, but not in serum, were independently associated with the severity of self-reported pain in OA patients. The inhibition of MIF signaling pathways may be a novel therapeutic approach for ameliorating OA-induced pain.

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Osteophyte growth in early thumb carpometacarpal osteoarthritis

Crisco

Morton

Moore

et al. 2019

Osteoarthritis and Cartilage

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Objective: Osteophyte formation is a critical part of the degeneration of a joint with osteoarthritis (OA). While often qualitatively described, few studies have succeeded in quantifying osteophyte growth over time. Using computed tomography (CT) image data from a longitudinal, observational study of thumb carpometacarpal (CMC) OA, our aim was to quantify osteophyte growth volume and location over a three-year period in men and women. Method: Ninety patients with early thumb OA were recruited and assessed at baseline, 1.5 years, and 3 years with CT imaging. Osteophyte volume and location on the trapezium and first metacarpal were determined using a library of 46 healthy subjects as a nonarthritic reference database. Results: There was a significant increase in osteophyte volume for women and men over the three-year follow-up in the trapezium (86.8 mm 3 e120.5 mm 3 and 165.1 mm 3 e235.3 mm 3 , means respectively) and in the proximal metacarpal (63 mm 3 e80.4 mm 3 , and 115.8 mm 3 e161.7 mm 3 , respectively). The location of osteophyte initiation and growth was consistent across subjects and was located in non-opposing regions on the trapezium and first metacarpal. Osteophyte growth occurred about the radial and ulnar margins of the trapezial facet, while on the proximal metacarpal, growth occurred principally about the volar and dorsal margins of the facet. Conclusion: Osteophyte growth occurred in early thumb osteoarthritis over three years. Growth was localized in specific, non-opposing regions on the trapezium and metacarpal, raising intriguing questions about the triggers for their formation, whether the mechanisms are mechanical, biological or a combination of both.

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Knee Joint Pain Potentially Due to Bone Alterations in a Knee Osteoarthritis Patient

Cited by 4 publications

References 11 publications

Osteoarthritis in the forefoot accompanied with joint pain is potentially associated with bone alterations

Osteoarthritis in the forefoot accompanied with joint pain is potentially associated with bone alterations

Synovial Fluid Macrophage Migration Inhibitory Factor Levels Correlate with Severity of Self-Reported Pain in Knee Osteoarthritis Patients

Osteophyte growth in early thumb carpometacarpal osteoarthritis

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