Knee Instability and Basic and Advanced Function Decline in Knee Osteoarthritis

Sharma, Leena; Chmiel, Joan S.; Almagor, Orit; Moisio, Kirsten C.; Chang, Alison H.; Belisle, L.; Zhang, Yunhui; Hayes, Karen

doi:10.1002/acr.22572

Cited by 29 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…response (MV) or maximum varus-valgus angular velocity (MVVV). During comfortable gait a higher MV and MVVV was observed in patients with KOA and (observed) varus thrust compared to patients with KOA and without varus thrust [22], but no difference was observed in VVE and MVV between patients with KOA-I and KOA-S [9]. Additionally, higher varusvalgus movement during comfortable gait was shown to be associated with knee confidence [7] and independent of joint laxity, muscle strength, skeletal alignment and knee joint proprioception [23].…”

Section: Varusvalgus Movementmentioning

confidence: 86%

“…The validity of such a measure needs to be proven, but since there is no such thing as a "golden standard" to validate a new measure against, studies are compelled to look at other levels of validity. In this review, studies looked for example at the ability to discriminate "stable" from "unstable" patients (previously divided in groups based on self-reported knee instability) [8,9,11,16,20,36,41,62,87,88,95] or the sensitivity of an intervention that is believed to be effective in improving knee stability [6,43,[49][50][51][57][58][59]68,83,100]. Unfortunately, the evidence of validity for the measures inventoried in this review was too limited or conflicting to recommend any of those as stability measure(s).…”

Section: Discussionmentioning

confidence: 99%

“…The literature search resulted in 89 eligible studies [6][7][8][9]11,15,16,[20][21][22][23]25,26,28,[30][31][32][33]. The characteristics of the eligible studies are presented in Table 1.…”

Section: Data Extractionmentioning

confidence: 99%

“…In the KOA population 63-76% of the patients report these sensations [2,6,7]. In addition, higher pain levels and lower physical function are reported in patients with selfreported 'unstable' knees compared to patients with self-reported 'stable' knees [8][9][10].…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Objective parameters to measure (in)stability of the knee joint during gait: A review of literature

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Varusvalgus Movementmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

“…The literature search resulted in 89 eligible studies [6][7][8][9]11,15,16,[20][21][22][23]25,26,28,[30][31][32][33]. The characteristics of the eligible studies are presented in Table 1.…”

Section: Data Extractionmentioning

confidence: 99%

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Objective parameters to measure (in)stability of the knee joint during gait: A review of literature

et al. 2019

View full text Add to dashboard Cite

show abstract

“…First, should the target be persons with knee OA or with pre-OA, defined here as at high risk for knee OA but not yet with radiographic disease? Risk factors for functional impairment, a precursor of disability in knee OA, have been identified 4–33. In persons with knee OA, OA disease and disease-exacerbated factors—for example, pain,4 5 7–9 28–30 buckling,21 33 decreased confidence,15 33 malalignment6 and proprioceptive inaccuracy9—have been associated with functional decline and may modify effects of factors like body weight.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of risk stratification trees for incident slow gait speed in persons at high risk for knee osteoarthritis

et al. 2019

Self Cite

View full text Add to dashboard Cite

ObjectivesDisability prevention strategies are more achievable before osteoarthritis disease drives impairment. It is critical to identify high-risk groups, for strategy implementation and trial eligibility. An established measure, gait speed is associated with disability and mortality. We sought to develop and validate risk stratification trees for incident slow gait in persons at high risk for knee osteoarthritis, feasible in community and clinical settings.MethodsOsteoarthritis Initiative (derivation cohort) and Multicenter Osteoarthritis Study (validation cohort) participants at high risk for knee osteoarthritis were included. Outcome was incident slow gait over up to 10-year follow-up. Derivation cohort classification and regression tree analysis identified predictors from easily assessed variables and developed risk stratification models, then applied to the validation cohort. Logistic regression compared risk group predictive values; area under the receiver operating characteristic curves (AUCs) summarised discrimination ability.Results1870 (derivation) and 1279 (validation) persons were included. The most parsimonious tree identified three risk groups, from stratification based on age and WOMAC Function. A 7-risk-group tree also included education, strenuous sport/recreational activity, obesity and depressive symptoms; outcome occurred in 11%, varying 0%–29 % (derivation) and 2%–23 % (validation) depending on risk group. AUCs were comparable in the two cohorts (7-risk-group tree, 0.75, 95% CI 0.72 to 0.78 (derivation); 0.72, 95% CI 0.68 to 0.76 (validation)).ConclusionsIn persons at high risk for knee osteoarthritis, easily acquired data can be used to identify those at high risk of incident functional impairment. Outcome risk varied greatly depending on tree-based risk group membership. These trees can inform individual awareness of risk for impaired function and define eligibility for prevention trials.

show abstract

Knee Confidence Trajectories Over Eight Years and Factors Associated With Poor Trajectories in Individuals With or at Risk for Knee Osteoarthritis

Chang

Lee

Almagor

et al. 2022

Arthritis Care & Research

View full text Add to dashboard Cite

To identify distinct trajectories of lack of knee confidence over an 8-year follow-up period and to examine baseline factors associated with poor trajectories in individuals with or at risk for knee osteoarthritis (OA).Methods. The Osteoarthritis Initiative is a prospective cohort study of individuals with or at high risk for knee OA. Confidence in the knees was assessed within the Knee Injury and Osteoarthritis Outcome Score instrument querying how much the individual is troubled by lack of confidence in his/her knee(s), rated as not-at-all (score = 0), mildly (score = 1), moderately (score = 2), severely (score = 3), and extremely (score = 4) troubled, reported annually from baseline to 96 months. Lack of knee confidence was defined as a score of ≥2. We used latent class models to identify subgroups that share similar underlying knee confidence trajectories over an 8-year period and multivariable multinomial logistic regression models to examine baseline factors associated with poor trajectories.Results. Among 4,515 participants (mean ± SD age 61.2 ± 9.2 years, mean ± SD BMI 28.6 ± 4.8 kg/m 2 ; 2,640 [58.5%] women), 4 distinct knee confidence trajectories were identified: persistently good (65.6%); declining (9.1%); poor, improving (13.9%); and persistently poor (11.4%). Baseline predictors associated with persistently poor confidence (reference: persistently good) were younger age, male sex, higher body mass index (BMI), depressive symptoms, more advanced radiographic disease, worse knee pain, weaker knee extensors, history of knee injury and surgery, and reported hip and/or ankle pain.Conclusion. Findings suggest the dynamic nature of self-reported knee confidence and that addressing modifiable factors (e.g., BMI, knee strength, depressive symptoms, and lower extremity pain) may improve its long-term course.

show abstract

Knee Instability and Basic and Advanced Function Decline in Knee Osteoarthritis

Cited by 29 publications

References 29 publications

Objective parameters to measure (in)stability of the knee joint during gait: A review of literature

Objective parameters to measure (in)stability of the knee joint during gait: A review of literature

Development and validation of risk stratification trees for incident slow gait speed in persons at high risk for knee osteoarthritis

Knee Confidence Trajectories Over Eight Years and Factors Associated With Poor Trajectories in Individuals With or at Risk for Knee Osteoarthritis

Contact Info

Product

Resources

About