Klug Death Acceptance Scale

Klug, Leo; Sinha, Arvind

doi:10.1037/t04679-000

Cited by 3 publications

(8 citation statements)

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“…Before the effect of oxygen on puf mRNA stability can be understood, it is necessary to study the principles of puf mRNA degradation, to understand the basis of differential stability of puf mRNA segments and to identify the oxygen-dependent steps in degradation. As outlined above, the mRNA secondary structure at the 3' end of the R. capsulatus, pufBA mRNA segment is essential for the higher stability of this mRNA species, presumably by protecting the upstream mRNA against 3' to 5' exonucleolytic attack (Chen etal.. 1988; Klug etal.. 1987 ; Fig. 2).…”

Section: Stabilization Of Pu^mrna Segmentsmentioning

confidence: 93%

“…A 0.5 kb mRNA species encodes the LHI proteins only, and half-lives of 22-33 min have been reported (Belasco et al. 1985;Klug etal., 1987). mRNA species of similar size LHI PC diflerenlial mRNA degradation CC Fig.…”

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

“…3) is responsible for its higher stability and consequently for the 10-15-fold molar excess of LHI complexes over RC complexes in the membrane (Belasco ef al., 1985). The removal of this secondary structure from the pufA-pufL intercistronic region indeed resulted in the loss of the 0.5 kb pu/ mRNA segment due to continuous degradation of the 2.7 kb mRNA species (Klug etal.. 1987;Chen etal., 1988). Asa consequence of the alteration of puf mRNA segment stability, the ratio of LHI versus RC complexes in the membrane decreased from 15:1 to 7:1 (KlugefaA, 1987).…”

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

“…Later steps in the expression of pu/genes, like translation or post-translational regulation, have not been studied to date, and their influence on the composition of the photosynthetic membrane is unknown. The altered stoichiometry of LHI and RC complexes after removal of the pufA-pufL intercistronic secondary structure resulted in decreased phototrophic growth rates in R. capsulatus strains lacking the LHII complex-When the LHIi complex was present, the removal of the intercistronic secondary structure did not affect the photosynthetic growth rate but resulted in a significantly prolonged lag phase when the bacteria were shifted from chemotrophic to phototrophic growth (Klug et al, 1987). Therefore, bacteria with wildtype stoichiometry of RC and LHI complexes are able to adapt much better to environmental changes.…”

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

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The role of mRNA degradation in the regulated expression of bacterial photosynthesis genes

Klug¹

1993

Molecular Microbiology

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Regulation of gene expression in bacteria, as in eukaryotic cells, is often achieved by variation of mRNA levels. Since the steady state levels of mRNA depend on both the rate of synthesis and the rate of decay, both mechanisms are important for gene regulation. After considerable effort undertaken over many years to understand the regulation of transcription, mRNA degradation has recently gained increasing attention as an important step in the regulation of some bacterial genes, and many investigations have addressed the mechanisms involved in mRNA decay. The puf mRNA of Rhodobacter capsulatus encoding pigment binding proteins has become a model system to study decay of a polycistronic mRNA and the role of mRNA degradation in gene expression. Individual segments of the polycistronic puf mRNA display extremely different half-lives. These differences in stability of mRNA segments are involved in the differential expression of puf encoded genes and consequently contribute to the stoichiometry of light-harvesting I and reaction centre complexes that results in optimal growth. In addition, control of mRNA stability is involved in the oxygen-dependent regulation of photosynthesis genes. High oxygen tension results in decreased stability of the reaction-centre specific puf mRNA segment, most likely by affecting the rate of endonucleolytic cleavage within the reaction centre coding region. The results obtained from studying puf mRNA degradation in R. capsulatus and Escherichia coli suggest that a specific distribution of decay promoting and decay impeding mRNA elements along the polycistronic mRNA is responsible for the different half-lives of individual puf segments.

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Section: Stabilization Of Pu^mrna Segmentsmentioning

confidence: 93%

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

Section: The Differential Stability Of Pu/mrna Segments Influences Thmentioning

confidence: 99%

See 2 more Smart Citations

The role of mRNA degradation in the regulated expression of bacterial photosynthesis genes

Klug¹

1993

Molecular Microbiology

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“…Thus different pathways and/or rates of degradation can be followed in the same operon. This is also observed in the malEFG operon of £ coli, the his transport operon of Satmonelta typhimurium (Newbury etat., 1987), and the pufoperon of Rhodobacter capsutatus (Klug et at., 1987). The atp operon differs from the aforementioned operons, however, in that its unstable region is located at the very beginning of the polycistronic message (compare with Baga et ai.…”

Section: The Significance Of Polycistronic Organization For Gene Exprmentioning

confidence: 99%

Post‐transcriptional control in the polycistronic operon environment: studies of the atp operon of Escherichia coli

McCarthy

1990

Molecular Microbiology

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Post-transcriptional control mechanisms assume special significance in polycistronic operons. Differential gene expression in the atp operon of Escherichia coli is primarily attributable to translational control and, to a lesser extent, to control of mRNA stability. At the same time, the polycistronic environment influences, to varying degrees, the relative importance of the different types of post-transcriptional control. The present article briefly reviews more recent results obtained through studies of the atp operon. Investigations of the pathway and kinetics of mRNA decay have yielded new information about the role of degradative mechanisms in the overall scheme of control. Moreover, translational coupling has been shown to feature as a major form of interaction between the atp genes. The relevance of these and other data is discussed in the wider context of the post-transcriptional control mechanisms generally available to E. coli.

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The neurogenetic background of parental care

Fazekas¹

2020

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ARC -nucleus arcuatus BGI -Beijing Genomics Institute blAmy -basolateral amygdala BSA -bovine serum albumin BST -bed nucleus of the stria terminalis BSTl -lateral subdivision of bed nucleus of stria terminalis BSTm -medial part of the bed nucleus of stria terminalis BSTmd -medio-dorsal subdivision of bed nucleus of stria terminalis BSTmv -medio-ventral subdivision of bed nucleus of stria terminalis Cb -cerebellum CDL -dorsolateral corticoid area cDNA -copy DNA CHAT -choline-o-acetyltransferase co -optic chiasm CLDN1 -caludin 1 CP -posterior commissure CRYM -crystallin mu CT -cycle threshold D1 -type 1 dopamine receptor D2 -type 2 dopamine receptor DA -dopamine DAT -dopamine transporter DEG -differentially expressed gene dmSt -dorsomedial striatum E -entopallium EA -extended amygdala EG -experimental group ERa -estrogen alpha receptor FA -frontoamygdaloid tract FC -fold change FLM -longitudinal medial tract Fos-ir -Fos immunoreactive FRL -lateral reticular formation GABA -gamma aminobutyric acid GAPDH -glyceraldehyde 3-phosphate dehydrogenase GCt -central gray GLM -generalised linear model GnIH -gonadotropin-inhibitory hormone GOI -gene of interest GP -globus pallidus HA -apical hyperpallium HDC -Histidine decarboxylase HF -hippocampal formation Hip -hippocampus HPRT -hypoxanthine phosphoribosyltransferase HVC -high vocal centre IAPP -islet amyloid polypeptide ICo -intercollicular nucleus

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Klug Death Acceptance Scale

Cited by 3 publications

References 0 publications

The role of mRNA degradation in the regulated expression of bacterial photosynthesis genes

The role of mRNA degradation in the regulated expression of bacterial photosynthesis genes

Post‐transcriptional control in the polycistronic operon environment: studies of the atp operon of Escherichia coli

The neurogenetic background of parental care

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