Klotho plays a role in reno protective effect of allopurinol on renal ischemia-reperfusion injury
Zeinab Karimi,
Pooran Ghahramani,
Fatemeh Masjedi
et al.
Abstract:Allopurinol, a xanthine oxidase inhibitor, recovers histological alterations and renal dysfunction induced during renal ischemic-reperfusion injury. This study investigated the cross-talk between the allopurinol and soluble klotho. Method and material: Rats were randomly divided into three equal groups (n = 8 per group): The sham-operated group without renal ischemia, the BIR (bilateral ischemia-reperfusion) group which underwent renal ischemia, and the BIR + Allo (allopurinol) group which was pretreated with… Show more
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