Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury

Gao, Wei; Yuan, Cheng; Zhang, Jingying; Li, Lingling; Yu, Li; Wiegman, Coen; Barnes, Peter J.; Adcock, Ian M.; Huang, Mao; Yao, Xin

doi:10.1042/cs20150273

Cited by 78 publications

(65 citation statements)

References 44 publications

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“…Previous studies have shown that klotho mRNA is expressed mainly in the brain, kidney, reproductive organs, pituitary gland, and parathyroid glands (8,9). We recently demonstrated that Klotho is also expressed in the lung and is down-regulated in the tissue in COPD lung (10).…”

Section: Abnormal Inflammation and Accelerated Decline In Lung Functimentioning

confidence: 93%

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

Wang

Gao

et al. 2015

Journal of Biological Chemistry

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Background:The role of Klotho in airway inflammation in COPD remains unclear. Results: Klotho expression was reduced in alveolar macrophages in peripheral lungs and PBMCs of smokers with and without COPD. Klotho regulates macrophage inflammation via NF-B pathway. Conclusion: Klotho plays a role in sustained inflammation of the lungs. Significance: These findings suggest Klotho may have therapeutic implications in COPD.

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Section: Abnormal Inflammation and Accelerated Decline In Lung Functimentioning

confidence: 93%

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

Wang

Gao

et al. 2015

Journal of Biological Chemistry

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“…Aged animals had increased lung inflammation, with higher levels of inflammatory cells and mediators associated with lower repair. Two studies from 2015 observed that Klotho, an anti-ageing protein with anti-inflammatory properties, is reduced in alveolar macrophages [111] and airway epithelial cells of patients with COPD [112]. The reduction was associated with high levels of oxidative stress, inflammation and apoptosis [111,112].…”

Section: Cellular Processesmentioning

confidence: 99%

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

et al. 2017

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Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients.In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.

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“…More recently, it has been demonstrated that Klotho is reduced in the airway epithelial cells and alveolar macrophages of both smokers and COPD patients (12,13) and that cigarette smoke reduces Klotho expression which subsequently confers augmented inflammation (13). Putative roles for smoking and physical activity in the aetiology of skeletal muscle weakness are not mutually exclusive.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Furthermore, current smoking status seems to attenuate circulating (14,15) and airway (12,13) Klotho levels. Since in developed countries smoking is the usual aetiological factor in COPD, a pathophysiological role for Klotho signalling in the development of skeletal muscle function deficits is possible; however there are currently no data available on human Klotho protein within skeletal muscle.…”

Section: Introductionmentioning

confidence: 98%

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Klotho and smoking – An interplay influencing the skeletal muscle function deficits that occur in COPD

Patel

Donaldson

Lewis

et al. 2016

Respiratory Medicine

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Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury

Abstract: This study evaluated the loss of Klotho in human lungs with COPD and the underlying mechanisms.

Cited by 78 publications

References 44 publications

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Klotho and smoking – An interplay influencing the skeletal muscle function deficits that occur in COPD

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