Klinische Untersuchung zur Veränderung der kornealen Biomechanik bei Patienten mit systemischer Sklerodermie

Abstract

In the course of the disease SSc leads to various alterations in connective tissue, which can also involve corneal tissue. CCT becomes significantly thinner and simultaneously partially loses elastic properties and gains viscosity. This accounts for reduced IOP values with dynamic contour tonometry as well as with ORA-tonometry (Goldmann-correlated IOP, CCT-compensated IOP). This distinct pre-existing significant negative correlation between age and CH and CRF values in patients with SSc could be due to slight regression of the viscous components and diminution of corneal damping capacity.

Einflussnahme des Diabetes mellitus auf glaukomrelevante Untersuchungsergebnisse beim primären Offenwinkelglaukom

“…Hinzu kommt, dass auch die Hornhautdicke zahlreichen Einflüssen unterliegt, die die Bewertung der Hornhautdicke durch schwankende Ergebnisse erheblich erschweren. Beispiele hierfür sind eine Hornhautverdünnung bei der systemischen Sklerodermie [17] oder beim Morbus Parkinson [18].…”

“…In addition, corneal thickness is also subject to numerous influences that make evaluation of corneal thickness considerably more difficult due to fluctuating results. Examples include corneal thinning in systemic scleroderma [17] or Parkin-sonʼs disease [18].…”

On the Relationship between Corneal Biomechanics, Macrostructure, and Optical Properties

“…The biomechanical properties of the cornea are responsible for its shape and integrity, acting as a unique convergence point between balanced ductility to preserve aspherical geometry (and correct ocular refraction), stiffness to compensate the intraocular pressure, and an ultrastructure that allows optical transparency. Biomechanical properties of the cornea can be affected by systemic diseases such as diabetes [3,4] or sclerosis [5,6]. In particular, corneal keratoconus may compromise the biomechanical stability, modifying the microstructure [7], weakening mechanical strength [8] and leading to corneal protrusion [9,10], inducing optical aberrations [11,12] that reduce the quality of vision or lead to transplants in advanced stages.…”