Klinische und experimentelle Untersuchungen über den Porphyrinstoffwechsel

Indolyl-3-acryloyl-glycine and the ‘Light Baud’ in Chronic Polymorphous Light Dermatosis

“…Note the Soret-band (405 mu, porphyrins) and the exact position of the maximum of the " light band", which is not identical to the maximum of IAcrGly (510 mu). IFiri/'(1954) and Schuppli (1958) this "light band" was present in nearly all 90 extracts; even if there exists no clear-cut maximum there is at least a "shoulder" in the curve (Fig. 2).…”

“…These investigations have never been confirmed in spite of num er ous trials by other authors (Schuppli, 1957(Schuppli, , 1958Burckhardl, 1959;Moroni, 1959) and on further consideration they can be rejected on purely theoretical grounds. In animals (paramecium and white mice) a photodynam ic action of the " light band extract" was dem onstrated w ithout previous sensitization, but in men a positive reaction to photo patch tests was only found in light sensitive patients and not in controls and the explanation of these last results was based on the concept of photoallergy; it is not clear why no photodynam ic action was found in men.…”

“…On the other hand, the specificity of the "light band" has been con firmed outside Ham burg, but only in small and rather haphazard investigations (Moroni, 1959;van Caneghem and Leloup, 1960;Katzenellenbogen, 1962); system atic investigations (Schuppli, 1957(Schuppli, , 1958 gave few indications of its specificity.…”