Klinik und Pathophysiologie des Karzinoids und Karzinoidsyndroms unter besonderer Berücksichtigung der Pharmakologie des 5-Hydroxytryptamins

Kähler, Hans; Heilmeyer, Ludwig

doi:10.1007/978-3-642-94808-4_7

Cited by 13 publications

(3 citation statements)

References 329 publications

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“…The clinical symptoms of the carcinoid syndrome are listed in Table 3, which has been compiled by Kaehler and Heilmeyer [51] from 138 cases published during the first five years after Waldenstro ¨m's description of the syndrome. No new data have had to be added to the table, which lists the symptoms according to the organs involved.…”

Section: Clinical Syndromes Due To Carcinoidsmentioning

confidence: 99%

Carcinoid Tumors: Development of Our Knowledge

Creutzfeldt

1996

World j. surg.

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Historically, carcinoids have long been known to be a morphologically distinct class of rare intestinal tumors that behave less aggressively than the more common intestinal adenocarcinomas. It was not until much later that their endocrine nature was recognized. Some authors restrict the term carcinoid to intestinal endocrine tumors, whereas others include a large variety of neuroendocrine tumors. In the WHO classification of 1980, carcinoids were defined as tumors of the diffuse neuroendocrine system that are either benign or neoplasms with a more favored prognosis than carcinomas. They are characterized by a typical growth pattern, silver affinity, and positive immunohistochemical reaction with neuron-specific markers; and they can express different peptides and biogenic amines. Neuroendocrine tumors originating from endocrine glands (pituitary, thyroid, adrenals, pancreas) and highly malignant neuroendocrine carcinomas are excluded from the carcinoid group of neoplasms. For the natural history of carcinoid tumors several independent predictive parameters can be defined: size, site of origin, growth pattern, and hormone dependence. The number of neuropeptides and amines expressed by a carcinoid or the amount of biologically active neurohormones secreted are of no prognostic significance regarding malignant behavior. The carcinoid syndrome is a rare clinical entity that occurs with a prevalence of 1.6% for carcinoid tumors and almost only if liver metastases are present. The complex clinical symptoms are only partially explained by the secretion of serotonin and tachykinins.

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Section: Clinical Syndromes Due To Carcinoidsmentioning

confidence: 99%

Carcinoid Tumors: Development of Our Knowledge

Creutzfeldt

1996

World j. surg.

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“…Creutzfeldt and Stockman [10] drew attention to data published by Kahler and Heilmeyer [9], who had reviewed the symptoms in 138 patients reported in the literature during the late 1950s. They reported that 51 patients (37%) had experienced abdominal cramping, this being the third most common symptom after flushing (68%) and diarrhea (57%).…”

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confidence: 99%

Clinical Manifestations of Carcinoid Disease

et al. 1996

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Carcinoid tumors are relatively uncommon tumors and their presentation is varied. For these reasons, a high index of suspicion is necessary in order to consider the diagnosis. It is important to separate the "syndrome" from the primary tumor. It is obviously more effective to diagnose the tumor itself before the syndrome manifests itself, usually as a result of metastatic disease. Since the tumors are characteristically slow-growing, the physician may be misled into thinking the patient has functional problems rather than a tumor. Some data and guidelines are given for focusing on the signs and symptoms of carcinoid disease.

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“…The carcinoid syndrome has given rise to a literature disproportionate to its rarity (for review, see Kahler and Heilmeyer, 1961). Much of the interest it has aroused lies in the possible role of certain potent pharmacologically active agents deriving from tumour tissue in the pathogenesis of the usual physical signs of the condition (Sandler, 1968;Sandler, Karim, and Williams, 1968).…”

mentioning

confidence: 99%

Massive hepatic resection for the carcinoid syndrome

Zeegen¹,

Rothwell-Jackson²,

Sandler³

1969

Gut

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SUMMARY Removal of the right lobe of the liver which was occupied largely by metastases, together with resection of ileal primary tumours, brought about complete remission of symptoms and signs in a 43-year-old man with a six-year history of the carcinoid syndrome. Investigations should be orientated toward surgery. When practicable, radical surgery of the type described here appears to offer the best hope of alleviating the distressing clinical features of the condition.

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Klinik und Pathophysiologie des Karzinoids und Karzinoidsyndroms unter besonderer Berücksichtigung der Pharmakologie des 5-Hydroxytryptamins

Cited by 13 publications

References 329 publications

Carcinoid Tumors: Development of Our Knowledge

Carcinoid Tumors: Development of Our Knowledge

Clinical Manifestations of Carcinoid Disease

Massive hepatic resection for the carcinoid syndrome

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