Klinik der inneren Sekretion

Adrenocortical Stimulation Tests with ACTH: Developments and Changes of a Diagnostic Procedure

“…In secondary adrenal insufficiency, eosinopenia occured not later than 4 h after the last injection. More frequently used were administrat ions of various depot preparations of ACTH [40,51,73,95,126,128]. Most of the results were similar to those obtained from i.v.…”

“…[41,50,121,124], has not been very useful. Since this method did not give satisfactory results unless a constant diet was applied [73], it has soon been abandoned [83,123], Some authors used the hormone-in duced increase of potassium excretion as an indirect measure of adreno cortical function. Application of depot ACTH on several days was followed by a drop of the Na/K ratio in the urine [88].…”

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

“…According to this hypothesis, women would be protected against schizophrenia between puberty and menopause to some extent by their relatively high gonadal estrogen production during this time. Then, around age 45, several years before menopause sets in at a mean age of 51.4 years, estrogen production begins to fall [19]. Thus women would lose the protection estrogens give, which could account for their second peak of illness onset after age 45.…”

Bioavailability and LH-Suppressing Effect of Different Testosterone Preparations in Normal and Hypogonadal Men

“…In order to achieve levels consistently above the lower normal range, it appears necessary to apply a dose of 250 mg in biweekly intervals. At present longer intervals are generally recom mended (e.g., Labhart, 1971;Wood, 1975). One phenomenon common to all injectable preparations investigated is the observation of unphysiologically high plasma testosterone levels shortly after administration.…”