In an interdisciplinary project involving life, engineering and socio-economic sciences, the sensitivity to climate change of the hydrologic, ecological and socio-economic properties of the inner Weser estuary and its marshes are analysed and different response strategies are developed and evaluated. To manage the complex interdisciplinary research process, the project has been organised with a stringent 'vertical' and 'horizontal' structure. The 'scenario approach' is used to take uncertainty into account. The climate change scenario for the year 2050 includes a sea level rise, an increase in tidal amplitude and mean temperature (especially in spring and winter) and an increase in precipitation and wind speed. In the absence of countermeasures a multitude of 'negative' primary effects can be expected, including overtopping of dikes by waves, submersion of forelands, changes in freshwater inflow, residence time and water quality in the estuary and water levels in the drainage systems of the marshes. However, the overall impact for the region can primarily be assessed as 'medium' and, if possible mitigating measures are taken into account, overall impact should be 'low'. KEY WORDS: Climate change · Impact · Estuary · Regional scale · Interdisciplinary · UncertaintyResale or republication not permitted without written consent of the publisher