Kleine–Levin Syndrome: History and Brief Review

Pearce, Jms

doi:10.1159/000148694

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Die klinischen Merkmale des seltenen Kleine-Levin Syndroms (KLS) sind prolongierte Phasen der Hypersomnie, die ü ber mehrere Tage und Wochen andauern k ö nnen und gefolgt werden von Phasen des Wachseins, verbunden mit Hypersexualit ä t und Hyperphagie [99,100] . Diese Symptome erinnern an Formen des Winterschlafes bei verschiedenen homoiothermen Tieren und wird aus diesem Grund auch zu den St ö rungen der zirkadianen Rhythmik gez ä hlt.…”

Section: Kleine-levin Syndromunclassified

Genetik von Schlafstörungen

Young¹

2008

Klin Neurophysiol

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Section: Kleine-levin Syndromunclassified

Genetik von Schlafstörungen

Young¹

2008

Klin Neurophysiol

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“…The disease was named, “KLS” by Critchley in 1962 after Willi Kleine and Max Levin who studied multiple cases of hypersomnolence and emphasized the association of periodic somnolence with morbid hunger from 1925 to 1936. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Sleeping Beauty: Kleine-Levin syndrome

Mudgal

Jiloha

Kandpal

et al. 2014

Indian J Psychiatry

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Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder.

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“…Usually affecting adolescent males, episodes normally last up to a few weeks and terminates with total and spontaneous recovery. Possibly first reported by Brierre de Bosmont in 1862, the condition however received its name from Willi Kleine who, in 1925, reported a series of cases of periodic hypersomnia and also Max Levin who described a case of periodic hypersomnia and excessive appetite in 1930 2. Since then, only 186 cases were reported in America, Europe, Africa, Middle East and Asia in particular India, Japan, Taiwan, China and Pakistan 3.…”

Section: Introductionmentioning

confidence: 99%

Kleine Levin syndrome in Malaysia: first typical case

Bahari

Ahmad²

2012

Case Reports

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A 13-year-old boy presented with a 2 weeks history of tearfulness, childish behaviour, separation anxiety, hypersomnia, hyperphagia and sexual disinhibition following a brief episode of fever. He had been experiencing the episodes since he was seven. The episodes lasted from a few days to 3 weeks and would normally occur once in a year. Most of the time it started with fever and resolved spontaneously. In the past he described auditory hallucination but not this time. Examination revealed a slightly overweight adolescent male appearing appropriate to his age. During the session he was restless, sleepy and burst into tears frequently. He constantly asked his mother when he could go home to sleep. He was very childish and clung to his mother. He was given a trial of risperidone 1 mg to be taken once a day for 3 days. On follow-up he had completely recovered.

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Kleine–Levin Syndrome: History and Brief Review

Cited by 11 publications

References 20 publications

Genetik von Schlafstörungen

Genetik von Schlafstörungen

Sleeping Beauty: Kleine-Levin syndrome

Kleine Levin syndrome in Malaysia: first typical case

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