Klebsiella pneumoniae Brain Abscess in a Taiwanese Adult

Marcolini, Julio; Nguyen, Maria; Ericsson, Charles D.

doi:10.1053/jinf.2002.0957

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…As already commented, the CNS exhibits well organized innate immune reactions, and glial cells, in response to injury (32,33) and infections (141,142), are capable of mounting a quick and effective response to control an infection until the cells of the peripheral adaptative immune system can be recruited (143,144). Microglia and astrocytes respond functionally with cytokine and chemokine production (57,145) and they are capable of contributing to an inflammatory environment in the CNS (16,146) following a variety of infectious or inflammatory insults (52).…”

Section: Role Of Tlr4/il-1ri Signaling In Ethanol-induced Inflammatormentioning

confidence: 99%

Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors

Blanco

Guerri²

2007

Front Biosci

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The brain is one of the major target organs of ethanol actions, and its chronic and acute intoxication results in significant alterations in brain structure and function, and in some cases to neurodegeneration. Glial cells and Toll-like receptors (TLRs) are vital players in CNS immune response; dysregulation of this response plays an important role in brain damage and neurodegeneration. Ethanol has immunomodulatory effects and induces specific alterations in the TLRs response in many tissues. These actions depend on the cell type, ethanol dose and treatment duration, as well as the concomitant presence of pathogens and their characteristics. Recent findings indicate that low concentrations of ethanol (10 mM) promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators (iNOS, NO, COX-2), and by activating signaling pathways (IKK, MAPKs) and transcriptional factors (NF-kappaB, AP-1) implicated in inflammatory injury. TLR4/IL-1RI receptors may be involved in ethanol-mediated inflammatory signaling, since blocking these receptors abolishes the production of ethanol-induced inflammatory mediators and cell death. We propose that at low physiologically relevant concentrations, ethanol facilitates TLR4/IL-1RI recruitment into lipid rafts microdomains, leading to the activation and signaling of these receptors. In summary, current results suggest that TLR4/ IL-1RI are important targets of ethanol-induced inflammatory brain damage.

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Section: Role Of Tlr4/il-1ri Signaling In Ethanol-induced Inflammatormentioning

confidence: 99%

Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors

Blanco

Guerri²

2007

Front Biosci

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“…To our knowledge, the present case is the first report of a brain abscess due to K. pneumoniae in a liver‐transplanted child. This agent is also considered an unusual cause of brain abscess in otherwise healthy adults and children (5, 11–13), except in the population of Taiwan in which it has been described in association with liver abscess and diabetes (11, 14, 15).…”

Section: Discussionmentioning

confidence: 99%

“…K. pneumoniae has rarely been reported to cause brain abscess in transplanted individuals, and no information is available about the diagnostic and therapeutic management of this condition (9, 10). To our knowledge, the present case is the ¢rst report of a brain abscess due to K. pneumoniae in a liver-transplanted child.This agent is also considered an unusual cause of brain abscess in otherwise healthy adults and children (5, 11^13), except in the population of Taiwan in which it has been described in association with liver abscess and diabetes (11,14,15).…”

Section: Discussionmentioning

confidence: 99%

Brain abscess due to Klebsiella pneumoniae in a liver‐transplanted child

Vajro¹,

Sokal²,

Maddaluno³

et al. 2009

Transplant Infectious Dis

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Brain abscesses are a rare, severe complication of orthotopic liver transplantation (OLT). They are almost exclusively due to fungi, Nocardia, or Toxoplasma, and usually occur within months of surgery. Here we report the case of an adolescent who developed a brain abscess due to Klebsiella pneumoniae 11.5 years after OLT. Fever was absent and laboratory parameters were not indicative of infectious disease, and therefore the diagnosis of a central nervous system neoplasm was considered. Subsequent magnetic resonance imaging and spectroscopy led to a diagnosis of a brain abscess, and to prompt appropriate antibiotic treatment. This case shows that K. pneumoniae may cause a brain abscess long after liver transplantation. The appearance of neurological symptoms should alert clinicians to consider a brain abscess even in the absence of overt clinical/laboratory signs of inflammation, which may be blunted by chronic immunosuppression.

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Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions

Guerri

Pascual

2012

Neural-Immune Interactions in Brain Function and Alcohol Related Disorders

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Klebsiella pneumoniae Brain Abscess in a Taiwanese Adult

Cited by 4 publications

References 12 publications

Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors

Ethanol intake enhances inflammatory mediators in brain: role of glial cells and TLR4/IL-1RI receptors

Brain abscess due to Klebsiella pneumoniae in a liver‐transplanted child

Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions

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