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Abstract

Our data suggest that eosinophils may act as important elements in the pathology of HD by providing cellular ligands for TNF-superfamily receptors (CD40, CD30, CD95/Fas) able to transduce proliferation and antiapoptotic signals at the surface of H-RS cells. The presence on eosinophils of receptors for TNF ligands expressed by activated T cells (i.e., OX40L, FasL, CD40L, 4-1BBL), also suggest that eosinophils may contribute to the deregulated network of interactive signals between H-RS cells, T cells, and other surrounding reactive cells.

Stem Cell Factor and Hematopoiesis

“…298 Whether soluble cytokine recep-leukemic blasts from patients with acute lymphocytic leukemia rarely display the c-kit receptor. 272,275 Most non-Hodg-tors normally serve to modulate ligand bioactivity in vivo or whether they are a byproduct of cellular desensitization kin's lymphomas lack c-kit receptor expression, 40,276,277 with the exception of anaplastic large-cell lymphomas that can to the ligand remains unclear at present. Soluble c-kit receptor is released by human hematopoietic display the c-kit receptor.…”

“…276 Lymph nodes from patients with Hodgkin's disease also express the c-kit receptor. 276 The c-cells, mast cells, and endothelial cells 40,238,270,292 and circulates in normal human plasma at a concentration of approxi-kit receptor is ubiquitously found on human hematopoietic cell lines of the erythroid and megakaryocytic phenotypes mately 325 ng/mL. 299 The quantity of soluble c-kit receptor in the plasma exceeds that of SCF by a 30-fold molar ratio.…”

Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women's Health Study

“…The role of tumor-infiltrating eosinophils in cancer progression and survival has been examined in the studies of different cancers and differed by cancer type (reviewed in ( 14 , 15 )). Eosinophil accumulation was associated with poorer prognosis in cervical cancer( 16 ) and Hodgkin’s lymphoma,( 17 ) and better prognosis of head and neck, bladder, gastric cancer, and esophageal carcinoma,( 14 , 15 , 18 , 19 ) while the eosinophil role in oral cancer was inconsistent across studies. ( 20 ) Colorectal cancer provides the most consistent evidence for a beneficial role of eosinophils in cancer prognosis, despite the small size of most conducted studies and difference in their designs and statistical methods ( Supplementary Table 1 ).…”

Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue

“…Activation or viral transformation increases CD30 expression on B and T cells, including ␥␦ T cells (50,51). CD153 is expressed on activated T cells, monocytes and macrophages (32), eosinophils (52), neutrophils (53), and both normal and malignant B cells (54). Therefore, both CD30 and CD153 are expressed on cells expected to be present at the site of a poxvirus infection.…”