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Fanardjian, V.V.; Gevorkyan, O. V.; Mallina, Ravi; Melik-Musyan, A. B.; Meliksetyan, I. B.

doi:10.1023/a:1026660915069

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Furthermore, CatWalk XT ® parameters seem to show a good correlation with lesion size in experimental models of spinal cord injury indicating the crucial role of the spinal cord in gait coordination. The lack of correlation between CatWalk XT ® parameters and the lesion volume in the chronic phase after CCI could, on one hand, be explained by the high plasticity of rodent motor control after focal injury, which has been shown in multiple different lesion models before: After focal lesion of the corticospinal tract, utilization of other projections such as the cortico-rubral tract seems to reorganize and restore motor function after focal unilateral injuries in rodents and cats within days while the focal injury persists; however, this compensatory plasticity seems to be less pronounced in models of TBI when compared to models of, e.g., ischemic stroke [ 40 – 44 ]. On the other hand, it has been shown, that a unilateral CCI leads to bilateral structural degradation, which extends well beyond the focal unilateral lesion detectable by light microscopy, and therefore, might cause functional impairments, that cannot be attributed to the focal unilateral lesion alone [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Focal lesion size poorly correlates with motor function after experimental traumatic brain injury in mice

et al. 2022

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Background It remains unclear whether neurobehavioral testing adds significant information to histologic assessment of experimental traumatic brain injury (TBI) and if automated gait assessment using the CatWalk XT®, while shown to be effective in in the acute phase, is also effective in the chronic phase after experimental TBI. Therefore, we evaluated the correlation of CatWalk XT® parameters with histologic lesion volume and analyzed their temporal and spatial patterns over four weeks after trauma induction. Methods C57Bl/6 mice were subjected to controlled cortical impact (CCI). CatWalk XT® analysis was performed one day prior to surgery and together with the histological evaluation of lesion volume on postoperative days one, three, seven, 14 and 28. Temporal and spatial profiles of gait impairment were analyzed and a total of 100 CatWalk XT® parameters were correlated to lesion size. Results While in the first week after CCI, there was significant impairment of nearly all CatWalk XT® parameters, impairment of paw prints, intensities and dynamic movement parameters resolved thereafter; however, impairment of dynamic single paw parameters persisted up to four weeks. Correlation of the CatWalk XT® parameters with lesion volume was poor at all timepoints. Conclusion As CatWalk XT® parameters do not correlate with focal lesion size after CCI, gait assessment using the CatWalk XT® might add valuable information to solitary histologic evaluation of the injury site. While all CatWalk XT® parameters can be used for gait assessments in the first week after CCI, dynamic single paw parameters might be more relevant in the chronic phase after experimental TBI.

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Section: Discussionmentioning

confidence: 99%