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MacKillop, James; Menges, David; McGeary, John E.; Lisman, Stephen A.

doi:10.1186/1744-9081-3-11

Cited by 75 publications

(29 citation statements)

References 94 publications

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“…The findings of the current study suggest cues influence demand and craving for IT. Although considering research on cue effects in the substance use disorder literature is still in infancy (Acker & MacKillop, 2013;Amlung et al, 2012;MacKillop, Menges, McGeary, & Lisman, 2007;MacKillop et al, 2010) and because this is currently the only study examining tanning demand and craving using a cue-reactivity paradigm, further research is necessary.…”

Section: Discussionmentioning

confidence: 98%

“…Although HPTs are becoming increasingly popular in behavioral economic research on addictions (Bickel et al, 2011;Bickel et al, 2014;Jarmolowicz et al, 2016) and behavioral health in general , as of yet only one study has validated the TPT against two commonly used questionnaires in substance use disorder research. Given the growing number of validation studies in the substance use literature (e.g., alcohol and tobacco; Amlung et al, 2012;Amlung & MacKillop, 2014;Amlung et al, 2015;MacKillop et al, 2007;MacKillop & Lisman, 2008;MacKillop et al, 2010;Madden & Kalman, 2010), future research may attempt to validate the TPT with tanning specific addiction tools such as the Structured Interview for Tanning Abuse and Dependence (Hillhouse, Baker, Turrisi, Shields, Stapleton, Jain, & Longacre, 2012), the Tanning Pathology Scale (Heckman et al, 2014;Hillhouse et al, 2010), and experiential tasks.…”

Section: Discussionmentioning

confidence: 98%

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An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

2017

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Melanoma and other skin cancers have become the most commonly diagnosed cancers in the United States. Despite the well-established link between skin cancer and indoor tanning, approximately 30 million Americans report engaging in indoor tanning each year, and the majority of these users are white females aged 16 to 29 years. Although some studies have suggested that exposure to ultraviolet radiation may produce reinforcing effects in frequent tanners paralleling the characteristic features of substance use disorders, no previous study has explored the impact of tanningrelated cues on demand for tanning. The aim of the present study was to examine the effects of tanning-related cues on participants' behavioral economic demand and craving for indoor tanning. Participants were 23 undergraduate students (22 females, one male), each of whom underwent a cueexposure procedure consisting of experiencing neutral-and tanning-related cues. Results suggest that participants exhibited an increase in behavioral economic demand and selfreported craving in the condition associated with tanningrelated cues relative to neutral-cues. We conclude by discussing notable limitations and offering directions for future research.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

2017

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“…Moreover, performance for hypothetical alcohol has been shown to be highly correlated with performance for actual alcohol (Amlung et al, 2012). In addition, state-oriented purchase tasks capture cue-elicited increases in motivation for alcohol (MacKillop et al, 2010b, 2007). …”

Section: Introductionmentioning

confidence: 99%

Further validation of a marijuana purchase task

Aston

Metrik

MacKillop

2015

Drug and Alcohol Dependence

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140

154

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Background A valid measure of the relative economic value of marijuana is needed to characterize individual variation in the drug’s reinforcing value and inform evolving national marijuana policy. Relative drug value (demand) can be measured via purchase tasks, and demand for alcohol and cigarettes has been associated with craving, dependence, and treatment response. This study examined marijuana demand with a marijuana purchase task (MPT). Methods The 22-item self-report MPT was administered to 99 frequent marijuana users (37.4% female, 71.5% marijuana use days, 15.2% cannabis dependent). Results Pearson correlations indicated a negative relationship between intensity (free consumption) and age of initiation of regular use (r=−0.34, p<0.001), and positive associations with use days (r=0.26, p<0.05) and subjective craving (r=0.43, p<0.001). Omax (maximum expenditure) was positively associated with use days (r=0.29, p<0.01) and subjective craving (r=0.27, p<0.01). Income was not associated with demand. An exponential demand model provided an excellent fit to the data across users (R2=0.99). Group comparisons based on presence or absence of DSM-IV cannabis dependence symptoms revealed that users with any dependence symptoms showed significantly higher intensity of demand and more inelastic demand, reflecting greater insensitivity to price increases. Conclusions These results provide support for construct validity of the MPT, indicating its sensitivity to marijuana demand as a function of increasing cost, and its ability to differentiate between users with and without dependence symptoms. The MPT may denote abuse liability and is a valuable addition to the behavioral economic literature. Potential applications to marijuana pricing and tax policy are discussed.

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“…These variants were identified as potential genetic risk factors for cue-induced drug craving and subsequent relapse to substance use. Though other findings relating DRD4 VNTR allele and cue reactivity have been contradictory (MacKillop et al, 2007; van den Wildenberg et al, 2007), Hutchison et al (2002) found an association between this allele with greater cue-induced craving and arousal among smokers.…”

Section: Pharmacogenetics Of Drug Effects and Treatment Outcomementioning

confidence: 85%

A review of pharmacogenetic studies of substance-related disorders

Jones¹,

Comer²

2015

Drug and Alcohol Dependence

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Background Substance-related disorders (SRDs) are a major cause of morbidity and mortality worldwide. Family, twin, and adoption studies have demonstrated the substantial heritability of SRDs. To determine the impact of genetic variation on risk for SRD and the response to treatment, researchers have conducted a number of secondary data analyses and quasi-experimental studies that target one or more candidate gene variants. Methods This review examines studies in which candidate polymorphisms were examined as mediator variables to identify pharmacogenetic effects on subjective responses to drug administration or cues or outcomes of medication trials for SRDs. Efforts to use a meta-analytic approach to quantify these effects are premature because the number of available studies using similar methods and outcomes is limited, so the present review is qualitative. Results Findings from these studies provide preliminary evidence of clinically relevant pharmacogenetic effects. However, independent replication of these findings has been sparse. Conclusions Although this growing body of literature has produced conflicting results, improved statistical controls may help to clarify the findings. Additionally, the use of empirically derived sub-phenotypes (i.e., which serve to differentiate distinct groups of affected individuals) may also help to identify genetic mediators of pharmacologic response in relation to SRDs. The identification of genetic mediators can inform clinical care both by identifying risk factors for SRDs and predicting adverse events and therapeutic outcomes associated with specific pharmacotherapies.

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Untitled

Cited by 75 publications

References 94 publications

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

Further validation of a marijuana purchase task

A review of pharmacogenetic studies of substance-related disorders

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