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Giri, Anuradha Vivekanandan; Anandkumar, Nandini; Muthukumaran, Geetha; Pennathur, Gautam

doi:10.1186/1471-2180-4-11

Cited by 145 publications

(58 citation statements)

References 10 publications

(6 reference statements)

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“…However, at 37°C S. marcescens did not produce any pigment in nutrient broth and the culture broth was white in colour. In case of the powdered peanut broth pigment production was observed, even at 37°C, which was equal quantitatively to the amount produced in nutrient broth at 30°C (Giri et al 2004). The pigment production was enhanced in sesame seed broth even in the absence of any sugars, Glucose and maltose in powdered sesame seed medium inhibited the prodigiosin production at both 28 and 30°C.…”

Section: Factors Influencing Prodigiosin Productionmentioning

confidence: 97%

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Prodigiosin and its potential applications

2015

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Since a decade, there has been a strong consumer demand for more natural products. This has augmented inclination towards substitution of synthetic colorants with natural pigments. Natural pigments not only have the capacity to increase the marketability of products, they also demonstrate valuable biological activities as antioxidants and anticancer agents. There is a long history of exploitation of natural products produced by bacteria as sources of pharmaceutically important, bioactive compounds. Among natural pigments, pigments from microbial sources are potentially suitable alternatives to synthetic pigments. The red pigment prodigiosin (PG) has unusual properties, which have long been documented. The red-pigmented prodiginines are bioactive secondary metabolites produced by both Gram-negative and Gram-positive bacteria. Prodigiosins are characterized by a common pyrrolyl pyrromethene skeleton, and the biological role of these pigments in the producer organisms remains unclear. Bacterial prodigiosins and their synthetic derivatives are effective proapoptotic agents against various cancer cell lines, with multiple cellular targets including multi-drug resistant cells with little or no toxicity towards normal cell lines. However, research into the biology of pigment production will stimulate interest in the bioengineering of strains to synthesize useful prodiginine derivatives. This review article highlights the characteristics and potential applications of prodigiosin pigment from Serratia as prodigiosins are real potential therapeutic drugs.

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Section: Factors Influencing Prodigiosin Productionmentioning

confidence: 97%

“…A comparative study was done using powdered seed of sesame in water, nutrient broth and peptone glycerol broth on growth of S. marcescens (Giri et al 2004). Sesame seed was observed yield better prodigiosin.…”

Section: Factors Influencing Prodigiosin Productionmentioning

confidence: 99%

Prodigiosin and its potential applications

2015

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“…isolated from marine sediments which was later used as a clothing dye. The production of prodigiosin by Serratia marcescens is dependent on temperature and is significantly reduced at temperatures higher than 37˚C (Giri et al, 2004) optimized the growth of Serratia using a variety of media and they observed that a novel peanut seed broth resulted in significant enhancement of prodigiosin production. Prodigiosin possesses antibacterial, antifungal (Gulani et al, 2012), antiprotozoal (Croft et al, 2003), cytotoxic (Nakashima et al, 2005) antitumor (Pérez-Tomás et al 2003;Chang et al 2011), antimalarial (Isaka et al 2002;Patil et al, 2011) and anti-cancerous properties (Ho et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Isolation and virtual screening of antimicrobial prodigiosin pigment from oxalotrophic Serratia marcescens OX_R strain

Suryavanshi¹,

Waghmode²,

Bharti³

et al. 2016

J App Pharm Sci

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Prodigiosin a multifaceted secondary metabolite produced by Serratia spp. having great potential as a pharmaceutical. In the present study we demonstrate that oxalate supplementation in peptone glycerol production media increased organoleptic characters and yield of prodigiosin pigment extracted from oxalotrophic Serratia marcescens OX_R isolated from Indian bat guano sample. The pigment was demonstrated in-vitro as an antibacterial agent against common opportunistic skin surface pathogen Staphylococcus aureus NCIM 5021 strain as killing activity by agar well diffusion method. The docking analysis and pharmacophore modelling indicated that the probable mechanism of action of the prodigiosin was against Staphylococcus aureus DNA gyrase protein. The pigment was also found to efficiently dye both cotton and latex polymer. In summary, we describe here an oxalotrophic Serratia marcescens which may serve as a potent and economical resource of prodigiosin which owing to its dyeing and anti-bacterial activities finds future avenues to be developed as dressing material for nosocomial subjects or burn victim patients.

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“…The biosynthesis of prodigiosin by pigmented strain of Serratia marcescens under aerobic conditions in the batch culture is realized. The pigment production is highly variable among species Serratia and it depends on many factors such as the specific strain, the temperature, the incubation time, the illumination, the pH medium and others [2,5,12]. The illumination conditions (light/darkness) affected both the biosynthesis of prodigiosin and energetic metabolism of the pigmented strain ATCC 9986 Serratia marcescens were shown [8].…”

Section: Cell Growth and Prodigiosin Production Conditionsmentioning

confidence: 99%

Application of prodigiosin as a colorant for polyolefines

Ryazantseva¹,

Andreyeva²

2014

ABC

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Serratia marcescens strain 9986 is a producer of prodigiosin used as a dye of polyolefines (polyethylene, ultratene). The biosynthesis of pigment was closely connected with controlled growth parameters. A prodigiosin yield 0.2 -0.4 mg per l of culture medium in the batch culture under aerobic conditions was obtained. Prodigiosin was extracted from crude biomass treated by 0.1% of sodium dodecyl sulfate (SDS). This novel elaborated stage is necessary for thermostability a dye in polymer. The consumption of prodigiosin preparation is more economical in the technology of the coloration of polyolefines. The elaborated method has been manufactured for dyeing polyethylene by biological pigment-articles of the common use corresponding to the technological standard.

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Cited by 145 publications

References 10 publications

Prodigiosin and its potential applications

Prodigiosin and its potential applications

Isolation and virtual screening of antimicrobial prodigiosin pigment from oxalotrophic Serratia marcescens OX_R strain

Application of prodigiosin as a colorant for polyolefines

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