Kiwi fruit allergy: A review

Lucas, Jane S.; Lewis, Stuart; Hourihane, Jonathan

doi:10.1046/j.0905-6157.2003.00095.x

Cited by 112 publications

(67 citation statements)

References 60 publications

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“…Commercial planting began in New Zealand in the late 1930 s, and for the past three decades kiwifruit has been increasingly available worldwide. 1) In Korea, seedlings of kiwifruit were introduced in 1977 for the first time, and Korean kiwifruit have found their way onto the market since 1981. Kiwifruit contain many medicinally useful compounds such as vitamin C, carotenoids, flavonoids, minerals, and others.…”

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confidence: 99%

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Jung

Song

Han

et al. 2005

Biological & Pharmaceutical Bulletin

101

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It is currently accepted that the consumption of fruit-derived antioxidants such as vitamin C, carotenoids, and flavonoids provides a preventive effect against cardiovascular disease. The purpose of the present study was to investigate potential cardiovascular protective properties of aqueous and 70% ethanol extracts from kiwifruit by analyzing the antioxidative, antihypertensive, hypocholesterolemic, and fibrinolytic activities in vitro. Aqueous and 70% ethanol extracts at 50 mg/ml showed DPPH-radical scavenging activities of 72.31% and 70.75%, respectively. Total antioxidant activity in linoleic acid emulsion was 85-88% at 10 mg/ml and 96-98% at 50 mg/ml of kiwifruit extract. Inhibitory activities against angiogensin I-converting enzyme of kiwifruit extracts were 21-26% at 10 mg/ml and 46-49% at 50 mg/ml, and inhibitory activities on HMG-CoA reductase were 13-14% at 10 mg/ml and 19-30% at 50 mg/ml. Fibrinolytic activity of kiwifruit was also observed at a high concentration of 100 mg/ml in both aqueous and 70% EtOH extracts. Based on our results, kiwifruit have potential cardiovascular protective properties in vitro.

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confidence: 99%

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Jung

Song

Han

et al. 2005

Biological & Pharmaceutical Bulletin

101

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“…This suggests that there was no human health risk associated with StarLink corn, supporting EPA's own assessment that Cry9C had a low probability of allergenicity (Bucchini, 2002). In contrast, there have been numerous examples during the 20 th century of foods imported into countries that have led to lifethreatening allergic responses, such as the case with kiwi fruit (Lucas et al, 2003). No conventionally bred plants are screened for allergenicity, raising the question of whether the risk of the high scrutiny for transgenic plants is justified, when just the presence of Cry9C DNA in 1% of the corn based products was enough to trigger the StarLink recall (Dorey, 2000).…”

Section: Low-level Presence Of Regulated Biotechnology Materialsmentioning

confidence: 52%

Genetically Engineered Crops for Biofuel Production: Regulatory Perspectives

Lee

Chen

Nair

2008

Biotechnology and Genetic Engineering Reviews

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There are numerous challenges in realizing the potential of biofuels that many policy makers have envisioned. The technical challenges in making the production of biofuels economical and on a scale to replace a significant fraction of transportation fuel have been well described, along with the potential environmental concerns. The use of biotechnology can potentially address many of these technical challenges and environmental concerns, but brings significant regulatory hurdles that have not been discussed extensively in the scientific community. This review will give an overview of the approaches being developed to produce transgenic biofuel feedstocks, particularly cellulosic ethanol, and the regulatory process in the United States that oversees the development and commercialization of new transgenic plants. We hope to illustrate that the level of regulation for transgenic organisms is not proportional to their potential risk to human health or the environment, and that revisions to the regulatory system in the U.S. currently under consideration are necessary to streamline the process.

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“…Although allergen issues are present in many fruits to some extent, kiwifruit is recognized as a major elicitor of plant food allergies (Lucas et al, 2003;Mills et al, 2004). Multiple allergic proteins are contained in kiwifruit and the fruit is principally consumed fresh (Nishiyama, 2007).…”

Section: Discussionmentioning

confidence: 99%

Differential Constitution in Promoter Region Leads to a Phenotype with a Lower Allergic Actinidin Level in Yellow-fleshed Kiwifruit (<i>Actinidia chinensis</i>)

et al. 2018

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Actinidin is a major protein contained in kiwifruit (Actinidia spp.). While uptake of actinidin is beneficial to help gastric protein digestion with cysteine protease activity, the protein is also recognized as a major elicitor of allergy which can induce tingling in the oral cavity and occasionally severe anaphylactic reactions. Given that consumption of fresh kiwifruit has increased globally, development of Actinidia cultivars with lower level of actinidin is required to reduce the risk of allergenicity. In the present study, we examined variations in the actinidin level in Actinidia varieties. Among several varieties having trace amounts of actinidin, A. chinensis 'Kohi' was targeted to be analyzed for the molecular basis for the phenotype. 'Kohi' had below the detectable transcript level of Act1a, a critical gene for actinidin level. The upstream region of Act1a in 'Kohi' constituted different sequences from that of A. deliciosa 'Hayward', which has an active promoter for high expression of Act1a. The 'Kohi' sequence in the diverged region (upstream from −873 b) was rich in cytosine residues methylated at a higher level than in 'Hayward'. Our data suggest the possibility of novel epigenetic regulation to reduce the actinidin level. The molecular mechanism for the phenotype in 'Kohi' was differentiated from 'Hort16A', a globally popular cultivar with a low level of actinidin. This cultivar could be a choice as a genetic resource in breeding to develop cultivars with controlled actinidin levels.

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Kiwi fruit allergy: A review

Cited by 112 publications

References 60 publications

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Cardiovascular Protective Properties of Kiwifruit Extracts in Vitro

Genetically Engineered Crops for Biofuel Production: Regulatory Perspectives

Differential Constitution in Promoter Region Leads to a Phenotype with a Lower Allergic Actinidin Level in Yellow-fleshed Kiwifruit (<i>Actinidia chinensis</i>)

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