Kıvırcık Irkı Koyunlara Ait Bazı Biyokimyasal Değerlerin Belirlenmesi Üzerine Bir Araştırma

Udum, Duygu; Üstüner, Hakan; Belenli, Deniz; Uzabacı, Ender

doi:10.30782/uluvfd.163479

Cited by 1 publication

(2 citation statements)

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“…Similar to ALT and AST parameters, it was determined that there was no negative effect of PG on BUN and LDH, and these two parameters increased significantly over time. The results obtained are consistent with similar studies and are associated with growth physiology, similar to other parameters (Assunçao, 2012;dos Santos et al, 2015;Lopez-Vargas et al, 2022;Udum et al, 2013).…”

Section: Discussionsupporting

confidence: 91%

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Effects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism‐related parameters and liver gene and protein expression during different feeding periods

Yakan,

Özkan,

Kaya

et al. 2023

Animal Science Journal

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This study aimed to investigate the metabolic effects of propylene glycol (PG) over 60, 90, and 120 days in lambs. Seventy‐two weaned male lambs were allocated into three groups: control (Con), PG1.5 (1.5 mL/kg live weight0.75), and PG3 (3 mL/kg live weight0.75). Blood samples were collected at the beginning and slaughter days. Biochemical parameters (glucose, triglycerides, ALT, AST, LDH, BUN, and insulin) and gene and protein levels of peroxisome proliferator activated receptor gamma (PPARγ), diacylglycerol o‐acyltransferase 1 (DGAT1), carbohydrate responsive element binding protein (ChREBP), and sterol regulatory element binding transcription factor 1c (SREBP‐1c) in the liver were determined. Glucose in PG1.5 was increased on Day 60, while significant differences were observed in biochemical parameters except for insulin on the 60, 90, and 120 days. Biochemical parameters such as ALT, AST, LDH, and BUN increased over time, while triglycerides decreased. DGAT1 gene and protein levels were lower, while SREBP‐1c and PPARγ were higher in PG groups on Day 60. While SREBP‐1c was lower in PG1.5, ChREBP was higher in PG3 on Day 90. PPARγ, DGAT1, and ChREBP were upregulated in PG3 on Day 120. Positive correlations were found between proteins. The long‐term use of PG in lambs did not have detrimental effects on metabolism. The study provides valuable insights into the molecular mechanisms underlying the metabolic effects of PG in lambs, shedding light on its potential applications in lamb production.

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Section: Discussionsupporting

confidence: 91%

“…The increase in these parameters is known to be related to the energy content of the ration, diseases, and various chemicals (Giráldez et al, 2021; Murray et al, 2009). The increase in ALT and AST parameters over time, depending on liver physiology, is considered physiologically normal (dos Santos et al, 2015; Udum et al, 2013).…”

Section: Discussionmentioning

confidence: 99%