Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma

Redelman-Sidi, Gil; Grommes, Christian; Papanicolaou, Genovefa A.

doi:10.1007/s11060-010-0322-6

Cited by 15 publications

(12 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a review of the literature, the majority of patients infected with B. bronchiseptica had at least one predisposing disease such as acute lymphocytic leukemia,3 chronic lymphocytic leukemia,4,5 lymphopenia associated with temolozolide treatment for glioblastoma,6 cystic fibrosis7 or had undergone hematopoietic stem cell transplantation (HSCT),8,9 or lung transplantation 10. Our study adds three new cases of B. bronchiseptica pneumonia to the current literature, which includes a patient with malignant thymoma, a patient with adenocarcinoma of unknown primary origin with brain metastases, and a patient with a history of lung and supraglottic cancer.…”

Section: Discussionmentioning

confidence: 99%

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Yacoub

Katayama

Tran

et al. 2014

Mediterr J Hematol Infect Dis

View full text Add to dashboard Cite

Organisms that are not known to cause serious infection in the immunocompetent population can, in fact, cause devastating illness in immunosuppressed neutropenic populations especially those who are undergoing hematopoietic stem cell transplantation (HSCT), and solid organ transplantation or a history of malignancy. One organism of interest isolated from immunosuppressed patients at our institution was Bordetella bronchiseptica. It is known to cause respiratory tract disease in the animal population which includes dogs, cats, and rabbits. This organism rarely causes serious infection in the immunocompetent population. However; in immunosuppressed patients, it can cause serious pulmonary disease. We present three cases of B. bronchiseptica pneumonia in patients with a history of malignancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Yacoub

Katayama

Tran

et al. 2014

Mediterr J Hematol Infect Dis

View full text Add to dashboard Cite

show abstract

“…Seventeen cases of opportunistic infection related to immunosuppression were reported [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. The confounding effect of other chemotherapeutic agents was excluded by demonstrating either the lack of temporal relationship or the nonoccurrence of toxicity on continuation of these agents.…”

Section: Uncommon Infectionmentioning

confidence: 99%

Temozolomide-related idiosyncratic and other uncommon toxicities

Dixit

Baker²,

Walmsley³

et al. 2012

Anti-Cancer Drugs

View full text Add to dashboard Cite

Temozolomide (TMZ)-related idiosyncratic and other uncommon toxicities have been reported. To better characterize these toxicities and to identify any associated risk factors, we performed a systematic review. We searched the PubMed database, limited to the English language, published between 1999 and December 2011. We selected only those articles in which TMZ was temporally related and was the sole or main contributing chemotherapeutic drug to idiosyncratic drug reactions (IDRs) and other uncommon toxicities. Hematological IDRs are biopsy-proven aplastic anemia or grade V toxicity or grade IV toxicity with slow and incomplete hematological recovery. Seventy-three cases were identified, including 21 hematological IDRs, 31 nonhematological IDRs and uncommon infections, and 21 second primary cancers. With a caveat of publication and reporting bias, the following observations could be made. The hematological IDRs predominantly occurred in female patients (exact binomial two-tailed, P=0.0041) and most patients were receiving TMZ concomitantly with radiotherapy for glioma. The median duration of exposure to TMZ was 30 days and the median cumulative TMZ exposure was 2250 mg/m (range, 500-6900 mg/m). The sex predilection was not evident in nonhematological IDRs and other uncommon toxicities. TMZ-induced pneumonitis and cholestatic hepatitis are emerging as a nonhematological hypersensitive reaction and IDR, respectively. For TMZ-related myelodysplasia or leukemia, the cumulative dose of TMZ ranged from 1400 to 30 000 mg/m. The cumulative dose of TMZ was lower and latency was shorter with a previous exposure to other leukemogenic drugs, suggesting that TMZ may have augmented the leukemogenic potential of other drugs. Early appearance of profound myelosuppression during the course of TMZ and concurrent radiotherapy could be a hematological IDR, which warrants prompt investigations to exclude aplastic anemia. Myelodysplasia or leukemia developed after a median TMZ exposure of 15 g/m.

show abstract

“…In the series by Yacoub et al [12], no clear transmission from pets can be assumed. Redelmann-Sidid et al [13] reported recently a patient with glioblastoma on temozolomide therapy with kitten-transmitted B. bronchoseptica infection. Wernli et al [7] summarized recently eight cases of B. bronchoseptica infection in human beings, the majority of whom had severe underlying disease and three of whom had been exposed to cats.…”

Section: Discussionmentioning

confidence: 99%

“…Pneumonia is the most common manifestation in human beings, however, reports on other infections such as one patient with liver cirrhosis and spontaneous bacterial peritonitis caused by B. bronchiseptica are available [9]. There is evidence that transmission through animal vectors plays a key role [7,8,[13][14][15][16]. Register et al [8] documented transmission of B. bronchiseptica from a cat to a patient with cystic fibrosis.…”

mentioning

confidence: 99%

Bordetella bronchisepticaPneumonia Post-Liver Resection in a Patient with Liver Cirrhosis and Cholangiocarcinoma

BonattiHugo

CraigBrian

TheckumparampilNithin

et al. 2016

Surgical Infections Case Reports

View full text Add to dashboard Cite

Background: Although Bordetella bronchiseptica is primarily an animal pathogen, cases of human disease caused by this pathogen have been published recently, most frequently pneumonia in immunocompromised patients. In human disease, transmission through animal vectors may play a key role. Although no standardized sensitivity testing is available for this pathogen in human disease, animal isolates are sensitive to most b-lactam antibiotics. Case Report: A 62-year-old Caucasian male with Child-Pugh class A cirrhosis caused by chronic hepatitis C infection underwent uneventful left lateral segmentectomy for a 3 cm cholangiocarcinoma. Within 48 h, he developed altered mental status, temperature of 39.4°C, leukocytosis (white blood cell count: 13,000/mm 3), and dyspnea followed by hypotension requiring vasopressor support and intubation. Computed tomography (CT) scan demonstrated left lower lobe pneumonia. Empiric antibiotic therapy including vancomycin (1 g every 12 h) and piperacillin-tazobactam (3.5 g every 6 h) was initiated and his signs of sepsis resolved within two days. Bordetella bronchiseptica was cultured from sputum. Upon questioning, the patient reported close contact with several pet cats on the days prior to admission. Antibiotics were continued for a total of seven days and he was discharged in good condition doing well at his six-month follow-up. Conclusions: Immunocompromised patients may develop infection with Bordetella bronchiseptica especially if they are in close contact with animals known to be a reservoir of this pathogen. If diagnosed early and treated appropriately, the outcome is favorable.

show abstract

Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma

Cited by 15 publications

References 52 publications

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Temozolomide-related idiosyncratic and other uncommon toxicities

Bordetella bronchisepticaPneumonia Post-Liver Resection in a Patient with Liver Cirrhosis and Cholangiocarcinoma

Contact Info

Product

Resources

About