Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal‐fetal interface in recurrent spontaneous abortion
Yanhong Yang,
Saizhe Song,
Shuting Gu
et al.
Abstract:ProblemImmune factors are crucial in the development of recurrent spontaneous abortion (RSA). This study aimed to investigate whether kisspeptin regulates immune cells at the maternal‐fetal interface and whether G protein‐coupled receptor 54 (GPR54) is involved in this process, through which it contributes to the pathogenesis of RSA.Method of studyNormal pregnancy (NP) (CBA/J × BALB/c) and RSA (CBA/J × DBA/2) mouse models were established. NP mice received tail vein injections of PBS and KP234 (blocker of kiss… Show more
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