Kisspeptin and body weight homeostasis in relation to phenotypic features of polycystic ovary syndrome; metabolic regulation of reproduction

Rashad, Nearmeen M.; Al-sayed, Radwa M.; Yousef, Mohammed S.; Saraya, Yasser S.

doi:10.1016/j.dsx.2019.04.017

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…These findings were in contrast with those found in previous adult studies that showed association of kisspeptin and insulin sensitivity and GSIS [ 9 – 11 , 13 ]. In PCOS women, serum kisspeptin was negatively correlated with HOMA-IR, an index of insulin resistance [ 9 , 10 ]. In addition, a study in nonobese and obese women demonstrated a negative correlation between serum kisspeptin and HOMA-IR as well as fasting serum insulin levels [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

Sithinamsuwan

Mahachoklertwattana

Wankanit

et al. 2020

International Journal of Endocrinology

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Objective. Kisspeptin, a puberty control neuropeptide, has been discovered to have an additional role in metabolism and glucose homeostasis regulation. This study aimed to determine the association of serum kisspeptin with metabolic parameters and glucose metabolism in obese children. Design, Patients and Measurements. A cross-sectional study of 270 obese children was conducted. All children underwent an oral glucose tolerance test and had serum kisspeptin, glycated hemoglobin (HbA1c), and lipid profile measurements. Body fat mass was assessed by bioelectrical impedance analysis. Serum kisspeptin levels of both prepubertal and pubertal children with two HbA1c ranges, <5.7% (normal range) and 5.7–6.4% (prediabetes range), were analyzed and correlated with metabolic parameters and glucose metabolism status. Results. The median (IQR) serum kisspeptin level of only pubertal (not prepubertal) children with prediabetes HbA1c was higher than those with normal HbA1c (53.2 (33.9, 69.8) and 37.8 (29.6, 67.5) pg/mL; p = 0.015 , respectively). There were no differences in serum kisspeptin levels among children with different glucose metabolism status. During pubertal progression, serum kisspeptin reached the highest level at Tanner stage II only in obese boys. Additionally, there was a positive correlation between serum kisspeptin and HbA1c after adjusting for puberty (β = 12.87; p = 0.001 ). No correlations between serum kisspeptin and insulin sensitivity indices, insulin secretion indices, lipid profile, blood glucose, as well as percentage of body fat were demonstrated. Conclusions. Serum kisspeptin levels in pubertal obese children with prediabetes HbA1c were greater than those with normal HbA1c. Serum kisspeptin was positively associated with HbA1c, but not with glucose metabolism status.

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Section: Discussionmentioning

confidence: 99%

Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

Sithinamsuwan

Mahachoklertwattana

Wankanit

et al. 2020

International Journal of Endocrinology

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“…Five papers did not report separated information for control groups, 4 included duplicate information, and one did not report the primary outcome (Figure 1). Finally, a total of 18 studies were evaluated for qualitative and quantitative assessment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…The PCOS diagnosis followed (i) the Rotterdam criteria in 17 studies [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][45][46][47], and (ii) one study was based on the association of chronic anovulation (< 6 cycles in 12 months) with hyperandrogenemia [44]. Six studies were carried out in Turkey [33,37,38,41,42,47}, two in China [34,46], two in Iraq [29,39], and one in each of the following countries: Bulgaria [43], Egypt [45], Ghana [31], Greece [44], Korea [40], Kuwait [36], Saudi Arabia [35] and Sri Lanka [32]. Table 1 displays information on the location and period of study, number of participants, mean age and BMI of participants with and without PCOS, as well as the main findings of studies meta-analyzed.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Using the NOS scale, 13 studies were identified as high-quality [35][36][37][38][39][40][41][42][43][44][45][46][47], and the other five of moderate quality [29,[31][32][33][34] (Appendix A, eSupplementary Table 1). All publications identified the study population, patients were representative of average PCOS cases, and controls were derived from the same population as cases.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…Rashad NM 2019 [45] eTable 2. Publication bias assessment for outcomes reported in at least 10 studies, Egger's regression, and Kendall's tau.…”

Section: Appendix a Supplementary Datamentioning

confidence: 99%

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Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Pérez‐López

Ornat

López‐Baena

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: This systematic review and meta-analysis aimed to summarize the available evidence regarding circulating kisspeptin and anti-müllerian hormone (AMH) and the homeostasis model assessment of insulin resistance (HOMA-IR) index in adolescents and women with and without polycystic ovary syndrome (PCOS).Method: We performed a comprehensive literature search in Medline, Embase, Cochrane, Scopus, and Web of Science for studies evaluating circulating kisspeptin levels in women with and without PCOS published until September 24th, 2020. Coprimary outcomes were the HOMA-IR index and AMH. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as mean difference (MD) or standardized MD (SMD) and their 95% confidence interval (CI). The systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42020205030. Results: We evaluated 18 studies including, 1,282 PCOS cases and 977 controls. Participants with PCOS were younger (MD=-2.38 years, 95%CI -4.32 to -0.44), with higher BMI (MD=1.16, 95% CI 0.54 to 1.78), waist-to-hip ratio (MD=0.04, 95%CI 0.02 to 0.05), circulating kisspeptin (SMD=1.15, 95%CI 0.68 to 1.62), luteinizing hormone (SMD=1.29, 95%CI 0.76 to 1.83), AMH (SMD=0.97, 95%CI 0.60 to 1,34), total testosterone (SMD=2.48, 95%CI 1.73 to 3.23), free testosterone (SMD=1.37, 95%CI 0.56 to 2.17), and dehydroepiandrosterone sulfate (SMD=0.72, 95%CI 0.32 to 1.13) levels, and Ferriman-Galweg score (SMD = 5.08, 95%CI 2.76 to 7.39), and lower sex hormone-binding globulin level (SMD=-1.34, 95%CI -2.15 to -0.52). Besides, participants with PCOS had higher HOMA-IR index (SMD=0.76, 95%CI 0.35 to 1.17), and circulating insulin (SMD=0.75, 95%CI 0.30 to 1.19), leptin (SMD=2.82, 95%CI 1.35 to 4.29), and triglycerides (SMD=2.15, 95%CI 1.08 to 3.23) levels than participants without the syndrome. The meta-regression did not identify significant factors influencing circulating kisspeptin. Conclusion:Patients with PCOS showed higher kisspeptin, LH, insulin, AMH, and androgen levels and HOMA-IR index, and lower sex hormone-binding globulin levels than those without the syndrome.

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Emerging roles of kisspeptin/galanin in age-related metabolic disease

Fang

She

Zhao

et al. 2021

Mechanisms of Ageing and Development

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Kisspeptin and body weight homeostasis in relation to phenotypic features of polycystic ovary syndrome; metabolic regulation of reproduction

Cited by 9 publications

References 29 publications

Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Emerging roles of kisspeptin/galanin in age-related metabolic disease

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