KIRs and their HLA ligands in Remitting–Relapsing Multiple Sclerosis

Fusco, Caterina; Guerini, Franca Rosa; Nocera, Giustina; Ventrella, Gianluca; Caputo, Domenico; Valentino, M. A; Agliardi, Cristina; Gallotti, Jacopo; Morra, Vincenzo Brescia; Florio, Ciro

doi:10.1016/j.jneuroim.2010.08.004

Cited by 42 publications

(30 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients of European ancestry, predisposition to MS has been variably associated with the absence of the inhibitory KIR2DL3 (10) or the presence of activating KIR2DL5 and KIR3DS1 . In other studies, KIR2DS1 was found to be protective in MS (11, 12). In the largest previous study to-date, the HLA class I Bw4 motif was found to be protective in a Norwegian cohort, but no association was observed between KIR carrier frequencies and MS (13).…”

Section: Introductionmentioning

confidence: 56%

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans

et al. 2016

View full text Add to dashboard Cite

We investigated the role of the KIR loci and their HLA class I ligands in a large cohort of African American MS patients (N=907) and controls (N=1456). No significant differences in carrier frequencies for any KIR locus or haplotype were observed between cases and controls. However, examination of KIR in the context of their cognate HLA ligands revealed a strong protective effect for KIR3DL1 in combination with HLA-A and –B alleles bearing the Bw4 motif (p=10−8; OR=0.60, CI=0.50–0.71) and the Bw4 ligand alone (Table 3; p<10−6; OR=0.63, CI=0.53–0.75). The observed effect cannot be explained by either a specific HLA-B allele or by linkage disequilibrium with HLA-DRB1 or HLA-A. The protective effect was observed only in individuals who were not positive for the MS risk allele HLA-DRB1*15:01 (p<10−6; OR=0.61, CI=0.51–0.74). Our study, the first investigation of KIR and MS in African Americans, confirms and refines previous findings in a European cohort.

show abstract

Section: Introductionmentioning

confidence: 56%

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans

et al. 2016

View full text Add to dashboard Cite

show abstract

“…KIRs are found primarily on NK cells, but also on some T cell subsets, and regulate the killing function of these cells through the interaction of stimulatory or inhibitory KIRs with specific class I HLA molecules (Kaur et al 2013;Uhrberg 2005). Several recent studies have started to investigate the relationship of expression of specific KIRs in MS; thus far, each group has reported differences in one or the other of the KIRs in MS patients compared to healthy controls (Fusco et al 2010;Garcia-Leon et al 2011;Jelcic et al 2012;Lorentzen et al 2009), or in patients who make positive response to IFN-β, compared to those who don't (Martinez-Rodriguez et al 2010, 2011, but there is currently little consensus between studies. For many of the KIRs, the class I HLA ligands are still unknown, so this is an area where there is still much work to be done.…”

Section: Interaction Of Class I Hla With Kirsmentioning

confidence: 99%

The Role of HLA in MS Susceptibility and Phenotype

Greer

2014

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

View full text Add to dashboard Cite

One of the most consistent findings in multiple sclerosis (MS) is that development of MS is linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1*15:01; around 60 % of Caucasian MS patients carry this allele compared to 25-30 % of ethnically matched healthy individuals. However, other HLA molecules have also been linked to the development of MS. In this chapter, the association between different HLA types and susceptibility to MS will be reviewed, and other linkages between the carriage of specific HLA molecules and clinical and experimental findings in MS will be considered.

show abstract

“…[7] In humans, 17 highly homologous genes have been identified to date: 6 activating (KIR2DS1-5, and KIR3DS1), 9 inhibitory (KIR2DL1-4, KIR2DL5A, KIR2DL5B, and KIR3DL1-3), and 2 pseudogenes (KIR2DP1 and KIR3DP1). [8] Recent studies have shown strong associations between KIR and human leukocyte antigen genes with susceptibility to autoimmune diseases such as rheumatoid arthritis, [9,10] multiple sclerosis, [11] SLE, [12,13] type I diabetes (T1DM), [14,15] and type II diabetes (T2DM), [16,17] etc.…”

Section: Introductionmentioning

confidence: 99%

Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations

Liang

Ma²,

Tan³

2017

Medicine

View full text Add to dashboard Cite

Background:Recently, a growing number of studies show that the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms may play a role in the systemic lupus erythematosus (SLE) susceptibility. Nonetheless, the results were inconsistent. Thus, a meta-analysis was carried out by integrating multiple research to clarify the association between KIR polymorphisms and SLE susceptibility.Methods:The Web of Science, Embase (Ovid), PubMed, Elsevier Science Direct, the Chinese Biomedical Database and CNKI, Wanfang databases (last search was updated on May 15, 2016) were systematically searched to select studies on addressing the association between the KIR polymorphisms and susceptibility to SLE in populations. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated.Results:A total of 10 published case-control studies involving 1450 SLE patients and 1758 controls were available for this meta-analysis. Results suggested that KIR2DL1 might be a risk factor for SLE (OR 2DL1 =1.047, 95% CI=1.011–1.083) in all subjects. The KIR2DL3, KIR2DL5 were identified as protective factors for SLE in Asian populations (OR2DL3= 0.215, 95% CI = 0.077–0.598; OR2DL5 = 0.588, 95% CI = 0.393–0.881), but not in Caucasians.Conclusions:The meta-analysis results suggested that 2DL1 might be a potential risk factor and 2DL3, 2DL5 might be protective factors for SLE in Asians but not in Caucasians.

show abstract

KIRs and their HLA ligands in Remitting–Relapsing Multiple Sclerosis

Cited by 42 publications

References 39 publications

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans

The Role of HLA in MS Susceptibility and Phenotype

Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations

Contact Info

Product

Resources

About