Abstract:The extent of NaCl reabsorption in the early distal convoluted tubule (DCT1) via the apical Na+‐Cl− cotransporter (NCC) defines the sodium load of the ensuing late DCT (DCT2) and connecting tubule (CNT). DCT2 and CNT express the epithelial sodium channel (ENaC) and potassium Kir1.1 channel (ROMK) to perform electrogenic sodium‐dependent potassium secretion into the urine. Kidney‐specific deletion of Kir4.1 (Ks‐Kir4.1−/−) causes profound hypokalemia in mice, which may result from reduced DCT function and increa… Show more
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