KIR/HLA Ligand Incompatibility in Kidney Transplantation

Kunert, Kristina; Seiler, Marleen; Mashreghi, Mir‐Farzin; Klippert, Katrin; Schönemann, Constanze; Neumann, Konrad; Pratschke, Johann; Reinke, Petra; Volk, Hans‐Dieter; Kotsch, Katja

doi:10.1097/01.tp.0000290681.41859.41

Cited by 55 publications

(54 citation statements)

References 49 publications

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“…21 In a recent study of 69 kidney transplants, no association was found between individual KIR genes or KIR haplotypes and the occurrence of acute rejection when tapering their immunosuppressive regimen. 22 However, Kunert et al 23 demonstrated in 224 kidney transplants that patients without acute rejections had higher frequencies of KIR2DL2/KIR2DS2 although no association was found between acute rejections and KIR haplotypes.…”

Section: Discussionmentioning

confidence: 99%

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation

Erp

Graaf

Paantjens

et al. 2008

The Journal of Heart and Lung Transplantation

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Background:The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is associated with viral infections. Natural killer (NK) cells are involved in the lysis of viral infected cells, and their activation is largely controlled by activating and inhibitory killer immunoglobulin-like receptors (KIRs). We hypothesized that KIR ligand incompatibility and recipients' individual KIRs could influence the development of BOS and the incidence of cytomegalovirus reactivation after lung transplantation. Methods:The KIR gene contents were determined in 48 patients who received a lung transplant, and human leukocyte antigen (HLA)-Cw and HLA-Bw4 typing was performed on their respective donors. Results:BOS developed in 7 patients and cytomegalovirus reactivation occurred in 16. BOS developed in 5 of 19 patients homozygous for KIR haplotype A compared with 2 of 27 patients with KIR haplotype AB and B (homozygous; p ϭ 0.03; log-rank test). In none of the patients with BOS was the activating KIR2DS5 gene detected, whereas it was present in 35% of patients without BOS (p ϭ 0.04; log-rank test). No correlation was found between KIR gene content and cytomegalovirus reactivation. Conclusion: Our results suggest that the lack of activating KIRs may play an important role in the development of BOS but not in the control of cytomegalovirus reactivation after lung transplantation.

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Section: Discussionmentioning

confidence: 99%

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation

Erp

Graaf

Paantjens

et al. 2008

The Journal of Heart and Lung Transplantation

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“…Although a huge number of unique haplotypes are described, a few comparatively common haplotypes repeatedly account for greater than 90% of the KIR haplotypic variation detected within a specific population, and are observed throughout major ethnic groups. 166,167 Our recent work and that of others has shown that the prevalence of KIR haplotypes and specific combinations of cognate KIR and HLA allotypes are associated in autoimmune 162,[168][169][170] and infectious diseases such as human immunodeficiency virus (HIV) and hepatitis C, [171][172][173][174] cancer, 175,176 and are critical to the success of solid organ and haematopoietic stem cell transplant (HCT) [177][178][179][180] and pregnancy. [181][182][183][184][185] Although the correlation of HLA variation with neurological disease has been well documented, there is a paucity of studies aiming to evaluate the impact of NK cells or their receptors, including KIR in these diseases.…”

Section: Hla and Amyotrophic Lateral Sclerosismentioning

confidence: 99%

The immunogenetics of neurological disease

2017

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Summary Genes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin‐like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. The findings of immunogenetic association studies are consistent with a polygenic model of inheritance in the heterogeneous and multifactorial nature of complex traits in various neurological diseases. Future investigation is highly recommended to evaluate both coding and non‐coding variation in immunogenetic loci using high‐throughput high‐resolution next‐generation sequencing technologies in diverse ethnic groups to fully appreciate their role in neurological diseases.

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“…(16,22,23,(30)(31)(32). In SOT, recent studies suggest that specific KIR/HLA class I ligand combinations between donor and recipient might influence short-term graft outcome after renal transplantation (33,34). (20,21 (12,45,48 …”

Section: The Pivotal Roles Of Nk Cells and Kir Receptors To Eliminatementioning

confidence: 99%

Natural Killer Cell Receptor Repertoire and Their Ligands, and the Risk of CMV Infection After Kidney Transplantation

Hadaya¹,

Rham²,

Bandelier

et al. 2008

American Journal of Transplantation

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Cytomegalovirus (CMV) infection is the most common viral complication after solid organ transplantation (SOT). Whilst current immunosuppression is knownto impair antiviral-specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by immunosuppressive therapy remains to be determined. To address this, we compared the genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that the absence of the HLA-C ligand for inhibitory KIR and the presence of activating KIR genes in the recipients were both associated with a lower rate of CMV infection after transplantation. In a cohort of 17 recipients with acute CMV infection, NK cells were phenotyped over a period of time after diagnosis by their expression profile of C-type lectin receptors and capacity to secrete IFN-c . The increased expression of the activating C-type lectin receptors NKG2C and NKG2D was paralleled by the decreased IFN-c secretion during the early phase of CMV infection. In conclusion, our findings suggest that KIR/HLA genotype and expression of NKG2C and NKG2D might play a significant role in regulating NK cell function and anti-CMV immunity after kidney transplantation.

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KIR/HLA Ligand Incompatibility in Kidney Transplantation

Abstract: Our data illustrate that certain KIR/HLA class I ligand combinations between donor and recipient might influence graft short-term outcome after renal transplantation.

Cited by 55 publications

References 49 publications

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation

The immunogenetics of neurological disease

Natural Killer Cell Receptor Repertoire and Their Ligands, and the Risk of CMV Infection After Kidney Transplantation

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