KIR Gene and KIR Ligand Analysis to Predict Graft Rejection After Renal Transplantation

Kreijveld, Ellen; Meer, Arnold van der; Tijssen, Henk; Hilbrands, Luuk B.; Joosten, Irma

doi:10.1097/01.tp.0000286097.11173.70

Cited by 27 publications

(26 citation statements)

References 41 publications

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“…In our study no effect of the recipient's KIR genotype on the incidence of graft rejection and graft function was observed. Our results, obtained in a population undergoing regular protocol biopsies to detect subclinical rejection, therefore confirm and extend a recent report which also failed to show a correlation between the recipient's KIR genotype and the incidence of graft rejection (16).…”

Section: Discussionsupporting

confidence: 90%

The Number of Activating KIR Genes Inversely Correlates with the Rate of CMV Infection/Reactivation in Kidney Transplant Recipients

Stangel¹,

Elsässer²,

Hönger³

et al. 2008

American Journal of Transplantation

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Section: Discussionsupporting

confidence: 90%

The Number of Activating KIR Genes Inversely Correlates with the Rate of CMV Infection/Reactivation in Kidney Transplant Recipients

Stangel¹,

Elsässer²,

Hönger³

et al. 2008

American Journal of Transplantation

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“…Tran et al [37] studied an effect of KIR ligand (i.e., C1, C2, and Bw4) matching on graft survival in 1416 recipients of cadaver kidney (both first grafts and regrafts) from all inhabited continents, but did not detect any effect. Similarly negative result was obtained by Kreijveld et al [38] who tested not only KIR ligands, but also KIR genes themselves as well as combinations of both in Dutch population. On the other hand, upon testing a KIR polymorphism in HLA -identical recipient-donor pairs from U.S.A., Cirocco et al [39] obtained a result suggesting protective effect of KIR2DL2 and KIR2DS2 genes; however, their study was based on extremely low number of individuals (only 12 recipient-donor pairs).…”

Section: Discussionsupporting

confidence: 66%

Killer Immunoglobulin-like Receptor (KIR) and HLA Genotypes Affect the Outcome of Allogeneic Kidney Transplantation

et al. 2012

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BackgroundRecipient NK cells may detect the lack of recipient's (i.e., self) HLA antigens on donor renal tissue by means of their killer cell immunoglobulin-like receptors (KIRs). KIR genes are differently distributed in individuals, possibly contributing to differences in response to allogeneic graft.Methodology/Principal FindingsWe compared frequencies of 10 KIR genes by PCR-SSP in 93 kidney graft recipients rejecting allogeneic renal transplants with those in 190 recipients accepting grafts and 690 healthy control individuals. HLA matching results were drawn from medical records. We observed associations of both a full-length KIR2DS4 gene and its variant with 22-bp deletion with kidney graft rejection. This effect was modulated by the HLA-B,-DR matching, particularly in recipients who did not have glomerulonephritis but had both forms of KIR2DS4 gene. In contrast, in recipients with glomerulonephritis, HLA compatibility seemed to be much less important for graft rejection than the presence of KIR2DS4 gene. Simultaneous presence of both KIR2DS4 variants strongly increased the probability of rejection. Interestingly, KIR2DS5 seemed to protect the graft in the presence of KIR2DS4fl but in the absence of KIR2DS4del.Conclusions/SignificanceOur results suggest a protective role of KIR2DS5 in graft rejection and an association of KIR2DS4 with kidney rejection, particularly in recipients with glomerulonephritis.

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“…The KIR gene distribution in both donors and recipients is depicted in Fig. 1 and did not differ from the frequencies observed in healthy popu- lations [21,35]. Analysis of our cohort by use of the 'missing ligand' model (see Patients and Methods) revealed that missing a KIR-ligand in the donor-versusrecipient direction had no effect on LTX outcome (Table 2a).…”

Section: Ltx Outcome Is Not Influenced By Kir-ligand Mismatching or Dmentioning

confidence: 79%

Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome

Moroso

Meer

Tilanus

et al. 2011

Transplant International

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Summary Whether or not Natural Killer (NK) cells affect the immune response to solid organ allografts is still controversial. Main determinants of NK‐cell activation are specific HLA/killer‐cell immunoglobulin‐like receptors (KIR) interactions that, in transplantation, may induce NK‐cell alloreactivity. So far, in liver transplantation (LTX) donor‐versus‐recipient alloreactivity has not been investigated; in addition, studies of predicted recipient‐versus‐donor NK‐cell alloreactivity have led to contradicting results. We typed a cohort of LTX donors and recipients for HLA‐C/Bw4 and KIRs. We estimated the effect of NK‐cell alloreactivity, as predicted by classically used models, in the donor‐versus‐recipient direction. The results indicate that HLA/KIR mismatches in the donor‐versus‐recipient direction do not predict graft rejection nor graft or patient survival, suggesting that donor‐derived NK cells do not play a major role in LTX outcome. In addition, when considering predicted NK‐cell alloreactivity in the reverse direction (recipient‐versus‐donor), we first confirmed that donor HLA‐C genotype was not associated with acute rejection, graft or patient survival and secondly we found that none of the models describing NK‐cell alloreactivity could predict LTX outcome. Overall our observations suggest that, in contrast to what is shown in haematopoietic stem cell transplantation, donor‐derived NK cells may not contribute in preventing liver graft rejection, and that recipient‐versus‐donor NK‐cell alloreactivity does not predict LTX outcome.

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KIR Gene and KIR Ligand Analysis to Predict Graft Rejection After Renal Transplantation

Abstract: Our data suggest that in a setting where immunosuppression is reduced, prior analysis of NK cell reactivity cannot identify patients at risk for subsequent graft rejection.

Cited by 27 publications

References 41 publications

The Number of Activating KIR Genes Inversely Correlates with the Rate of CMV Infection/Reactivation in Kidney Transplant Recipients

The Number of Activating KIR Genes Inversely Correlates with the Rate of CMV Infection/Reactivation in Kidney Transplant Recipients

Killer Immunoglobulin-like Receptor (KIR) and HLA Genotypes Affect the Outcome of Allogeneic Kidney Transplantation

Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome

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