KipOTIA detoxifies 5-oxoproline and promotes the growth ofClostridioides difficile
Cheyenne D. Lee,
Arshad Rizvi,
Shonna M. McBride
Abstract:Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore formation under favorable growth conditions. In Bacillus subtilis, one such mechanism for preventing sporulation is the Kinase Inhibitory Protein, KipI, which impedes activation of the main sporulation kinase. In addition, KipI functions as part of a complex that detoxifies the… Show more
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