2019
DOI: 10.1101/849281
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Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

Abstract: Kinase-dependent signaling networks are frequently dysregulated in cancer, driving disease progression. While kinase inhibition has become an important therapeutic approach many cancers resist drug treatment. Therefore, we need both reliable biomarkers that predict drug responses and new targets to overcome drug resistance. Determining the kinase(s) that control cancer progression in individual cancers can pose a significant challenge. Genomics has identified important, yet limited numbers of kinase driver mut… Show more

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References 63 publications
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