Kink-free electrospun PET/PU-based vascular grafts with 3D-printed additive manufacturing reinforcement

Adhikari, Kiran R.; Zimmerman, Jordan; Dimble, Pravin S.; Tucker, Bernabe S.; Thomas, Vinoy

doi:10.1557/s43578-021-00291-6

Cited by 7 publications

(2 citation statements)

References 55 publications

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“…However, it has shown some limitations regarding its resistance to bending stresses, a phenomenon that can lead to cause either a discontinuity on the inner radius or a reduction in lumen diameter during the bending deformation. This effect, also known as kinking, can cause severe turbulence of the blood flow or even hinder the proper passage of blood, leading to the failure of the implant [ 24 ]. The SILKGraft vascular prosthesis is currently produced with a length of 10 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Kink resistance is a fundamental property for a vascular graft, as the kinking phenomenon can cause partial or total occlusion of the device lumen and interruption of the flow, with very serious consequences for its functionality and, when implanted, patient’s life. A recent trend to overcome the bottleneck of thepoor kinking behavior of polymeric tubular structures targeting vascular tissue regeneration is the adoption of manufacturing solutions resulting in an effective reinforcement of the tube in the radial direction, such as the insertion of spiral structures deposited by 3D printing [ 24 ] or the corrugation of the wall of the tube [ 33 ]. Significant improvements of the kink resistance were reported with both approaches.…”

Section: Discussionmentioning

confidence: 99%

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Silk Vascular Grafts with Optimized Mechanical Properties for the Repair and Regeneration of Small Caliber Blood Vessels

et al. 2022

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As the incidence of cardiovascular diseases has been growing in recent years, the need for small-diameter vascular grafts is increasing. Considering the limited success of synthetic grafts, vascular tissue engineering/repair/regeneration aim to find novel solutions. Silk fibroin (SF) has been widely investigated for the development of vascular grafts, due to its good biocompatibility, tailorable biodegradability, excellent mechanical properties, and minimal inflammatory reactions. In this study, a new generation of three-layered SF vascular scaffolds has been produced and optimized. Four designs of the SILKGraft vascular prosthesis have been developed with the aim of improving kink resistance and mechanical strength, without compromising the compliance with native vessels and the proven biocompatibility. A more compact arrangement of the textile layer allowed for the increase in the mechanical properties along the longitudinal and circumferential directions and the improvement of the compliance value, which approached that reported for the saphenous and umbilical veins. The higher braid density slightly affected the grafts’ morphology, increasing surface roughness, but the novel design mimicked the corrugation approach used for synthetic grafts, causing significant improvements in kink resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Silk Vascular Grafts with Optimized Mechanical Properties for the Repair and Regeneration of Small Caliber Blood Vessels

et al. 2022

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In Situ Functionalisation and Upcycling of Post‐Consumer Textile Blends into 3D Printable Nanocomposite Filaments

Apostolopoulou‐Kalkavoura,

Fijoł,

Lombardo

et al. 2024

Advanced Sustainable Systems

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The linear lifecycle of the textile industry contributes to the enormous waste generation of post‐consumer garments. Recycling or repurposing of post‐consumer garments typically requires separation of the individual components. This study describes a novel and facile chemo‐thermo‐mechanical method for producing extrudable pellets, involving one‐pot, 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl (TEMPO)‐mediated oxidation of post‐consumer polycotton textiles, followed by mild mechanical treatment, all without isolating the constituents of the polycotton blend. The oxidized blend with high cellulose and carboxylate content of 1221 ± 82 mmol COO− per kg of cotton, is pelletised into a masterbatch and further in situ extruded into nanocomposite filaments for 3D printing. The carboxyl groups introduced on the polycotton‐based filters enable cotton fibrillation into nanoscaled fibers during mechanical treatment and extrusion resulting to a variety of functional and high surface‐finish quality models, including filters and fashion accessories. The electrostatic interactions with positively charged species, such as methylene blue (MB), facilitate their adsorption from water while exhibiting promising adsorption capacities. The adsorption of MB follows the Freundlich model and depends on the printed porosity of the filter. A “trash to treasure” concept for textile waste is further corroborated through the use of the developed 3D printing filament into commodity products.

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PLA/HA Multiscale Nano-/Micro-Hybrid 3D Scaffolds Provide Inductive Cues to Stems Cells to Differentiate into an Osteogenic Lineage

Ayariga

Dean

Nyairo

et al. 2021

JOM

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Kink-free electrospun PET/PU-based vascular grafts with 3D-printed additive manufacturing reinforcement

Cited by 7 publications

References 55 publications

Silk Vascular Grafts with Optimized Mechanical Properties for the Repair and Regeneration of Small Caliber Blood Vessels

Silk Vascular Grafts with Optimized Mechanical Properties for the Repair and Regeneration of Small Caliber Blood Vessels

In Situ Functionalisation and Upcycling of Post‐Consumer Textile Blends into 3D Printable Nanocomposite Filaments

PLA/HA Multiscale Nano-/Micro-Hybrid 3D Scaffolds Provide Inductive Cues to Stems Cells to Differentiate into an Osteogenic Lineage

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