Kininogen present in rat reproductive tissues is apparently synthesized by the liver, not by the reproductive system

Hossain, Amjad; Whitman, Gail F.; Khan, Iqbal

doi:10.1016/0002-9378(95)90349-6

Cited by 14 publications

(14 citation statements)

References 16 publications

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“…These findings suggest that the contact system may play an important role in human reproduction. Interestingly, the female reproductive tract is the second richest site for kininogen and its metabolic products in the body [35][36][37][38]. Adam et al [38] measure 12.2, 10.9, 0.4 and 1.2 g/mg T-kininogen in rat plasma, uterus, liver, and kidney, respectively.…”

Section: Discussionmentioning

confidence: 97%

Certain Autoantibodies to Phosphatidylethanolamine (aPE) Recognize Factor XI and Prekallikrein Independently or in Addition to the Kininogens

Sugi

McIntyre

2001

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 97%

Certain Autoantibodies to Phosphatidylethanolamine (aPE) Recognize Factor XI and Prekallikrein Independently or in Addition to the Kininogens

Sugi

McIntyre

2001

Journal of Autoimmunity

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“…PE is a major component of both the outer and inner leaflets of cell plasma membranes and makes a complex with several plasma proteins, such as high-molecular weight kininogen, low-molecular weight kininogen, and proteins in complex with high-molecular weight kininogen, factor XI, or prekallikrein (40,41). Kininogen and its metabolites are abundantly expressed in the female reproductive system (42)(43)(44)(45). Furthermore, in antiphospholipid syndrome, which is clinically characterized by systemic thrombosis and recurrent pregnancy loss, anti-PE antibody recognizes the PE-binding proteins (40,41).…”

Section: Figure 10mentioning

confidence: 99%

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice

Mizugishi

Li²,

Olivera³

et al. 2007

J. Clin. Invest.

136

116

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Uterine decidualization, a process that occurs in response to embryo implantation, is critical for embryonic survival and thus is a key event for successful pregnancy. Here we show that the sphingolipid metabolic pathway is highly activated in the deciduum during pregnancy and disturbance of the pathway by disruption of sphingosine kinase (Sphk) genes causes defective decidualization with severely compromised uterine blood vessels, leading to early pregnancy loss. Sphk-deficient female mice (Sphk1 -/-Sphk2 +/-) exhibited both an enormous accumulation of dihydrosphingosine and sphingosine and a reduction in phosphatidylethanolamine levels in pregnant uteri. These mice also revealed increased cell death in decidual cells, decreased cell proliferation in undifferentiated stromal cells, and massive breakage of decidual blood vessels, leading to uterine hemorrhage and early embryonic lethality. Thus, sphingolipid metabolism regulates proper uterine decidualization and blood vessel stability. Our findings also suggest that disturbance in sphingolipid metabolism may be considered as a cause of pregnancy loss in humans. IntroductionEmbryonic implantation is a complex series of processes that establishes the connection between maternal and embryonic tissues and requires an intricate program of uterine preparation (1, 2). Very soon after implantation, which occurs in the mouse on day 4.5 postcoitum (pc) (day 0.5 - vaginal plug), endometrial stromal cells surrounding implanting blastocysts undergo dramatic transformation (decidualization), during which they proliferate and differentiate into decidual cells. Decidualization begins in the stromal region immediately surrounding the embryo (antimesometrial site). Next to the implanting blastocyst, thin, dense, avascular cell layers, called the primary decidual zone, are formed. Adjacent to the primary decidual zone, the broad secondary decidual zone is fully developed by day 6.5 pc, and is characterized by terminally differentiated decidual polyploidy with acquisition of large mono- or binucleated cells (3). The decidua provides a vascular network for nutrition and gas exchange for the developing embryo before a functional placenta is established (4). It also acts as a barrier to uncontrolled trophoblast proliferation.The sphingolipid metabolic pathway produces bioactive signaling metabolites as well as complex lipids that are utilized in membrane organization and structure. A very prominent signaling lipid is sphingosine-1-phosphate (S1P), which enhances cell survival and growth (5-8). Recent studies have demonstrated its physiologic importance in the development of the vascular and nervous system (9-12), the heart (13), and the immune system (14-16) by signaling through a family of G protein-coupled receptors designated S1P 1-5 . In contrast, 2 precursors of S1P,

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“…9 The kininogen concentration in reproductive tissues and plasma has been reported to fl uctuate during ovulation, pregnancy and parturition. 10 What governs the fl uctuation of kininogen concentrations remains to be elucidated. Sugi et al 9 demonstrated a strong association between RSA and antiphosphatidylethanolamine antibodies.…”

Section: Introductionmentioning

confidence: 99%

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

et al. 2005

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RESULTS: ACA was detected in 11 women with RSA and one fertile woman. Heterozygous C677T was detected in 59 women with RSA and 35 fertile women. Concomitant presence of ACA and C677T was found in eight women with RSA and no fertile women (p < 0.01). DISCUSSION:The meaning of the association between C677T mutation in the MTHFR gene and ACA is still not clear. It is possible that an inherited factor that alone would not strongly predispose a woman to thrombosis could, when associated with an acquired factor, start the process and increase the likelihood of thrombosis expression.CONCLUSIONS: ACA and C677T in the MTHFR gene are statistically associated with RSA. The association of these two conditions is a new fi nding in thrombogenic factors and RSA.

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Kininogen present in rat reproductive tissues is apparently synthesized by the liver, not by the reproductive system

Cited by 14 publications

References 16 publications

Certain Autoantibodies to Phosphatidylethanolamine (aPE) Recognize Factor XI and Prekallikrein Independently or in Addition to the Kininogens

Certain Autoantibodies to Phosphatidylethanolamine (aPE) Recognize Factor XI and Prekallikrein Independently or in Addition to the Kininogens

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

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