Kinin formation in the plasma and cerebral blood flow under conditions of cerebral ischemia/reperfusion in rats during modulation of kinin system activity

Abstract

Suppression of kininogenesis is an adaptive phenomenon in cerebral ischemia/reperfusion in rats aimed at elimination of the no-reflow phenomenon. Hyperkininogenesis and suppression of kinin destruction are pathogenetically significant, because they augment the manifestations of no-reflow phenomenon during reperfusion following ischemia.