1993
DOI: 10.1161/01.hyp.21.6.961
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Kinin actions on renal papillary blood flow and sodium excretion.

Abstract: Infusion of bradykinin into the renal medullary interstitium (0.1 /ig/min, n=6) significantly increased renal papillary blood flow as measured by laser-Doppler flowmetry to 117±3% of control without altering cortical blood flow or blood pressure in anesthetized Munich-Wistar rats. In animals prepared for clearance studies, renal medullary bradykinin infusion did not alter total renal blood flow, glomerular filtration rate, or renal interstitial hydrostatic pressure but increased urine flow by 100%, sodium excr… Show more

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Cited by 81 publications
(64 citation statements)
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“…Regarding the coronaries, our dynamic experiments show that local resistance is de- Ϫ/Ϫ mice. A potential role for bradykinin in the regulation of coronary resistance and/or blood flow has previously been hypothesized, [31][32][33][34] but to our knowledge, the present study is the first to document in vivo the consequences of a constitutive deficiency of the B 2 receptor in this vascular bed. As expected, dipyridamole infusion elicits no renal vasodilatation in B 2 Ϫ/Ϫ and WT mice, thus confirming the selectivity of this vasodilator agent for the coronary vasculature.…”
Section: Discussionmentioning
confidence: 80%
“…Regarding the coronaries, our dynamic experiments show that local resistance is de- Ϫ/Ϫ mice. A potential role for bradykinin in the regulation of coronary resistance and/or blood flow has previously been hypothesized, [31][32][33][34] but to our knowledge, the present study is the first to document in vivo the consequences of a constitutive deficiency of the B 2 receptor in this vascular bed. As expected, dipyridamole infusion elicits no renal vasodilatation in B 2 Ϫ/Ϫ and WT mice, thus confirming the selectivity of this vasodilator agent for the coronary vasculature.…”
Section: Discussionmentioning
confidence: 80%
“…No changes of cortical flow were observed. Similarly, infusions of bradykinin (57) and acetylcholine (62), NO-dependent vasodilators, also produced substantial increases of MBF. Several important conclusions were drawn from these in vivo studies in anesthetized rats.…”
Section: Initial Evidence That No Participates In the Acute Regulatiomentioning
confidence: 89%
“…Changes in renal CBF are not always replicated in the medullary or papillary regions because medullary hemodynamics can be regulated independently of renal CBF (Pallone et al 1990, Navar et al 1996, Mattson 2003. Vasoactive agents, including AngII, dopamine, arginine vasopressin, atrial natriuretic peptide, and bradykinin have been demonstrated to induce renal region-specific hemodynamic changes (Takezawa et al 1987, Pallone et al 1990, Nobes et al 1991, Mattson & Cowley 1993, Heyman et al 1995, Badzynska et al 2002, Igbe et al 2012. However, the effect of UII on regional RBF was unclear.…”
Section: Discussionmentioning
confidence: 99%